Thrombosis associated with acute cytomegalovirus infection: A meta-analysis
Thrombosis associated with acute cytomegalovirus infection: A meta-analysis
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DOI：
10.1016/j.ejim.2010.11.006
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发表时间：
2011-04-01
影响因子：
8
通讯作者：
Steinvil, Arie
中科院分区：
文献类型：
--
作者：
Justo, Dan;Finn, Talya;Steinvil, Arie
背景：到目前为止，在医学文献中已经报道了近100次与急性巨细胞病毒（CMV）感染相关的血栓形成。尽管如此，这两种情况下的患者的临床特征从来没有系统的审查和described.Methods：文献检索进行了所有（n = 97）关于血栓形成与急性CMV感染的报告。结果：急性巨细胞病毒感染住院患者中血栓形成的发生率为6.4%，血栓形成住院患者中急性巨细胞病毒感染的发生率为1.9-9.1%。大多数（n = 64; 65.9%）报告的患者具有免疫功能。报告患者的平均年龄为39.7 ± 14.9岁。男女比例为1：1。DVT/PE、内脏静脉血栓形成和脾梗死是与急性CMV感染相关的最常见血栓形成。虽然DVT/PE在免疫功能低下的患者中更常见，但内脏静脉血栓形成在免疫功能正常的患者中更常见。血栓形成的遗传易感性在免疫功能正常的患者中明显更普遍。免疫功能低下的患者更常接受抗病毒药物治疗。报告的患者之间抗凝治疗的持续时间存在显著差异。结论：临床医师应警惕急性CMV感染患者的血栓形成症状和体征，并对血栓形成患者的急性CMV感染症状和体征给予高度重视。(C)2010年欧洲内科联合会。由Elsevier B.V.出版，版权所有。
Background: Thrombosis associated with acute cytomegalovirus (CMV) infection has been reported in the medical literature almost 100 times thus far. Still, the clinical characteristics of patients with both conditions have never been systematically reviewed and described.Methods: A literature search was conducted for all (n=97) reports concerning thrombosis associated with acute CMV infection. The current knowledge concerning this unique association and previous clinical experience are presented here.Results: The incidence of thrombosis among acute CMV infection hospitalized patients was 6.4%, and the incidence of acute CMV infection among thrombosis hospitalized patients was 1.9-9.1%. Most (n=64; 65.9%) reported patients were immunocompetent. Mean age of reported patients was 39.7 +/- 14.9 years. Female-male ratio was 1:1. DVT/PE, splanchnic vein thrombosis and splenic infarction were the most prevalent thromboses associated with acute CMV infection. While DVT/PE was more prevalent among immunocompromised patients, splanchnic vein thrombosis was more prevalent among immunocompetent patients. Inherited predispositions for thrombosis were significantly more prevalent among immunocompetent patients. Immunocompromised patients were treated with antiviral agents significantly more often. Duration of anticoagulation therapy varied significantly between reported patients. In-hospital mortality rates were 4.9-22.2%.Conclusions: We believe physicians should be alert for symptoms and signs of thrombosis in patients with acute CMV infection, and for symptoms and signs of acute CMV infection in patients with thrombosis. (C) 2010 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.