Ventromedial Frontal Lobe Damage Disrupts Value Maximization in Humans
Ventromedial Frontal Lobe Damage Disrupts Value Maximization in Humans
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DOI：
10.1523/jneurosci.6527-10.2011
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发表时间：
2011-05-18
影响因子：
5.3
通讯作者：
Kable, Joseph W.
中科院分区：
文献类型：
--
作者：
Camille, Nathalie;Griffiths, Cathryn A.;Kable, Joseph W.
最近的神经经济学研究表明，眼窝额叶皮层和内侧前额叶皮层的区域在选择过程中对不同选项的主观价值进行编码。然而，这些电生理学和神经影像学研究并不能证明这些信号对于价值最大化的选择是否必要。在这里，我们使用了实验经济学中开发的范式来经验地测量和量化腹内侧额叶（VMF）损伤的人类对效用理论的违反。我们发现，有这种损害的人更有可能做出违背揭示偏好的广义公理的选择，而揭示偏好是选择符合价值最大化的一个充分必要条件。这些结果表明，VMF在价值最大化选择中起着至关重要的作用。
Recent work in neuroeconomics has shown that regions in orbitofrontal and medial prefrontal cortex encode the subjective value of different options during choice. However, these electrophysiological and neuroimaging studies cannot demonstrate whether such signals are necessary for value-maximizing choices. Here we used a paradigm developed in experimental economics to empirically measure and quantify violations of utility theory in humans with damage to the ventromedial frontal lobe (VMF). We show that people with such damage are more likely to make choices that violate the generalized axiom of revealed preference, which is the one necessary and sufficient condition for choices to be consistent with value maximization. These results demonstrate that the VMF plays a critical role in value-maximizing choice.