Application of Adipose-Derived Stem Cells in Heart Disease
Application of Adipose-Derived Stem Cells in Heart Disease
复制标题
脂肪干细胞在心脏病中的应用
DOI：
10.1007/s12265-014-9585-1
复制
发表时间：
2014-10-01
影响因子：
3.4
通讯作者：
Xu, Jianguo
中科院分区：
文献类型：
--
作者：
Chen, Lina;Qin, Fengming;Xu, Jianguo
Therapy with mesenchymal stem cells is one of the promising tools to improve outcomes after myocardial infarction. Adipose-derived stem cells (ASCs) are an ideal source of mesenchymal stem cells due to their abundance and ease of preparation. Studies in animal models of myocardial infarction have demonstrated the ability of injected ASCs to engraft and differentiate into cardiomyocytes and vasculature cells. ASCs secrete a wide array of angiogenic and anti-apoptotic paracrine factors such as vascular endothelial growth factor, hepatocyte growth factor, and insulin-like growth factor 1. ASCs are capable of enhancing heart function, reducing myocardial infarction, promoting vascularization, and reversing remodeling in the ischemically injured hearts. Furthermore, several ongoing clinical trials using ASCs are producing promising results for heart diseases. This article reviews the isolation, differentiation, immunoregulatory properties, mechanisms of action, animal models, and ongoing clinical trials of ASCs for cardiac disease.
