Plasticity in Early Alzheimer Disease An Opportunity for Intervention
Plasticity in Early Alzheimer Disease An Opportunity for Intervention
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DOI：
10.1097/tgr.0b013e31821e588e
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发表时间：
2011-10-01
影响因子：
0.5
通讯作者：
Gill, David J.
中科院分区：
文献类型：
--
作者：
Hill, Nikki L.;Kolanowski, Ann M.;Gill, David J.
可塑性的科学证据，即大脑在一生中改变其组织和激活的动态能力，在过去十年中显著增加。这篇分析性综述评估了关于早期阿尔茨海默病(AD)患者可塑性持续存在的选定证据。功能神经成像提供了令人信服的证据，证明在整个衰老和痴呆的早期阶段都有可塑性，包括在AD的前驱时期反应增强的可能性。行为结果研究表明，早期阿尔茨海默病患者在进行以认知为重点的干预后，能够重新学习以前被遗忘的信息或以其他方式改善认知能力。这两个证据都支持代偿过程的存在，即使在痴呆症相关病理存在的情况下也是如此。大脑保留的这种适应神经退行性疾病以试图维持功能的能力可能为干预提供了宝贵的机会，特别是在AD的前驱或早期阶段。
The scientific evidence of plasticity, or the brain's dynamic ability to alter its organization and activation throughout one's lifetime, has increased significantly over the last decade. This analytic review evaluates selected evidence regarding the persistence of plasticity in people with early-stage Alzheimer disease (AD). Functional neuroimaging provides persuasive evidence of plasticity throughout aging as well as the early stages of dementia, including the possibility of a heightened response during the prodromal period of AD. Behavioral outcomes research demonstrates the ability of people with early-stage AD to relearn previously forgotten information or otherwise improve cognitive abilities after a cognition-focused intervention. Both of these bodies of evidence support the existence of compensatory processes at work, even in the presence of dementia-related pathology. This retained ability of the brain to adapt to neurodegenerative disease in an attempt to maintain function may provide a valuable opportunity for intervention, particularly in the prodromal or earliest stages of AD.