Involvement of the optic tectum and mesencephalic reticular formation in the generation of saccadic eye movements in goldfish
Involvement of the optic tectum and mesencephalic reticular formation in the generation of saccadic eye movements in goldfish
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DOI：
10.1016/j.brainresrev.2004.10.002
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发表时间：
2005-09-01
影响因子：
--
通讯作者：
Torres, B
中科院分区：
文献类型：
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作者：
Luque, MA;Pérez-Pérez, MP;Torres, B
跳跃性眼动产生的电路和生理特性主要是在猴子和猫身上研究的。相比之下，目前关于非哺乳动物物种的知识相当匮乏。我们在这里回顾了我们最近的一些发现，关于视觉顶盖和中脑网状结构参与了金鱼扫视的产生。视神经顶盖的电微刺激会引起眼球的对立性跳动。金鱼和哺乳动物一样，扫视的幅度和方向被编码在空间地形图中。此外，还有一些区域已经进化了，比如极端的前内侧顶盖区，它的激活产生了眼睛会聚。双向示踪生物素葡聚糖胺注射在功能确定的位置的盖帽提供互惠的，位置依赖的连接与不同的下游结构。在这些结构中，主要的构造目标是中脑网状结构。与哺乳动物一样，金鱼的中脑网状结构和视直肠在区域和神经元层面建立了相互连接，支持反馈回路的存在。微电刺激表明，中脑网状结构可以在功能上被包裹——吻侧部分与垂直扫视有关，而尾侧部分与水平扫视有关。最后，这些区域与视直肠的连接方式也不同。根据这些数据，我们得出结论，金鱼眼动产生中涉及的视直肠和中脑网状结构与猫和猴子相似。(c) 2004 Elsevier B.V.版权所有
The circuitry and physiological properties underlying saccadic eye movement generation have been studied mainly in monkeys and cats. By contrast, current knowledge in nonmammalian species is rather scarce. We review here some of our recent findings about the involvement of the optic tectum and mesencephalic reticular formation in the generation of saccades in goldfish. Electrical microstimulation of the optic tectum evokes contraversive saccadic eye movements. In goldfish, as in mammals, the amplitude and direction of saccades are encoded in a spatial topographical map. In addition, there are some areas that have evolved, such as the extreme anteromedial tectal zone, whose activation yields eye convergence. Injections of the bidirectional tracer biotin dextran amine within functionally identified sites of the tectum provide reciprocal, site-dependent connectivity with different downstream structures. Of these structures, the major tectofugal target is the mesencephalic reticular formation. In goldfish, as in mammals, the mesencephalic reticular formation and optic rectum establish reciprocal connections at regional and neuronal levels which support the presence of feedback circuits. Electrical microstimulation demonstrates that the mesencephalic reticular formation can be functionally parceled-the rostral part is linked to vertical saccades, while the caudal part is related with horizontal ones. Finally, these zones are also differently connected to the optic rectum. From these data, we conclude that the involvement of the optic rectum and mesencephalic reticular formation in eye movement generation in goldfish is similar to that reported in cats and monkeys. (c) 2004 Elsevier B.V. All rights reserved.