The electroencephalographic effects of desflurane in humans.
The electroencephalographic effects of desflurane in humans.
复制标题
地氟烷对人体的脑电图影响。
DOI：
10.1097/00000542-199103000-00008
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发表时间：
1991
期刊：
影响因子：
8.8
通讯作者：
Cahalan,MK
中科院分区：
文献类型：
--
作者：
Rampil,IJ;Lockhart,SH;Eger2nd,EI;Yasuda,N;Weiskopf,RB;Cahalan,MK
一种新的吸入麻醉剂的脑电图（EEG）效应引起了人们的兴趣，因为这种药物有可能产生兴奋性（惊厥）活动，也因为脑电图作为麻醉深度和大脑活动指标的潜在用途。因此，我们检查了12名健康的年轻男性志愿者在地氟醚麻醉下的脑电图。每位受试者进行基线记录，然后稳定暴露于单独的O2中6,9和12%（0.83,1.24和1.66 MAC）的地氟醚，以及60% N2O的O2中3,6和9%的地氟醚。给药顺序和N2O的存在是随机的。我们使用机械通气维持每个剂量水平的正常碳酸血症。我们还测试了自发性通气继发高碳酸血症的影响。此外，在1.24 MAC时，受试者的肺部过度通气至二氧化碳分压25.8+/-0.7 mmHg，并暴露于有节奏的大声鼓掌中，试图引起兴奋现象。最后，在地氟醚暴露至少6小时后，我们在0.83和1.66 MAC下重复测量以评估可能的耐受性。视觉监测4个脑电通道，并在每次给药时进行定量脑电分析。地氟醚产生的脑电图变化与异氟醚等效水平的观察结果相当。未见癫痫样活动。地氟醚显著抑制脑电活动；显著的突破抑制见于1.24 MAC及更高水平。用N2O代替0.42 MAC的地氟醚，相对于同等效力的地氟醚和O2，降低了脑电图抑制程度。早期剂量和后期重复暴露的定量脑电图测量没有差异。
The electroencephalographic (EEG) effects of a new inhaled anesthetic are of interest because of the potential of such agents to produce excitatory (convulsant) activity and because of the potential usefulness of the EEG as an indicator of anesthetic depth and cerebral activity. Accordingly, we examined the EEG in 12 healthy, young male volunteers during desflurane anesthesia. Each subject had a baseline recording and then steady-state exposure to 6, 9, and 12%(0.83, 1.24, and 1.66 MAC) desflurane in O2 alone, and to 3, 6, and 9% desflurane in O2 with 60% N2O. The sequence of doses and the presence of N2O were randomized. We used mechanical ventilation to maintain normocapnia at each dose level. We also tested the effects of hypercapnia secondary to spontaneous ventilation. Additionally, at 1.24 MAC, subjects' lungs were hyperventilated to a PCO2 of 25.8+/-0.7 mmHg and exposed to rhythmic, loud clapping to attempt to provoke excitatory phenomena. Finally, after at least 6 h exposure to desflurane, we repeated measurements at 0.83 and 1.66 MAC to assess possible tolerance. Four channels of EEG were monitored visually, and at each dose, a quantitative EEG analysis was performed. Desflurane produced EEG changes comparable to those observed with equipotent levels of isoflurane. No epileptiform activity was seen. Desflurane significantly suppressed EEG activity; prominent burst suppression was seen at 1.24 MAC and higher. Substitution of N2O for 0.42 MAC desflurane reduced the degree of EEG suppression relative to the equipotent administration of desflurane and O2. Quantitative EEG measures for the early doses and for the later, repeated exposures did not differ.