MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions.
MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions.
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DOI：
10.4255/mcpharmacol.11.13
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Girish C. Shukla;Jagjit Singh;S. Barik
中科院分区：
文献类型：
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作者：
Girish C. Shukla;Jagjit Singh;S. Barik
小的非编码microRNA（miRNAs）的显着发现及其在转录后基因调控中的作用揭示了遗传信息表达的另一个微调步骤。大量的细胞通路，在生物体发育中起作用，在健康和疾病中很重要，似乎是由miRNA调节的。在分子水平上，miRNA通过影响其靶mRNA的稳定性和/或通过下调其翻译来抑制蛋白质的产生。本文综述了miRNA在动物中的编码、加工、靶点识别和功能。我们的目标是为读者提供一个发人深省的和机械的介绍miRNA的世界，而不是一个详细的百科全书。
The remarkable discovery of small noncoding microRNAs (miRNAs) and their role in posttranscriptional gene regulation have revealed another fine-tuning step in the expression of genetic information. A large number of cellular pathways, which act in organismal development and are important in health and disease, appear to be modulated by miRNAs. At the molecular level, miRNAs restrain the production of proteins by affecting the stability of their target mRNA and/or by down-regulating their translation. This review attempts to offer a snapshot of aspects of miRNA coding, processing, target recognition and function in animals. Our goal here is to provide the readers with a thought-provoking and mechanistic introduction to the miRNA world rather than with a detailed encyclopedia.