Can the prostate risk calculator based on western population be applied to asian population?
Can the prostate risk calculator based on western population be applied to asian population?
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DOI：
10.1002/pros.21475
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发表时间：
2012-05-01
期刊：
影响因子：
2.8
通讯作者：
Schroder, Fritz H.
中科院分区：
文献类型：
--
作者：
Yoon, Duck Ki;Park, Jae Young;Schroder, Fritz H.
背景我们开发了韩国前列腺癌风险计算器 (KPCRC)，用于使用韩国男性人群的临床和实验室数据预测初始前列腺活检阳性的概率 (http://pcrc.korea.ac.kr)。我们根据欧洲前列腺癌筛查随机研究 (ERSPC) 荷兰部分的数据，将其性能与前列腺特异性抗原 (PSA) 测试和前列腺风险计算器 3 (PRC 3) 进行比较，该研究预测先前未筛查男性的活检结果。方法 数据收集自 602 名韩国男性，他们之前未经筛查，并接受了最初的十芯前列腺活检。进行多重逻辑回归分析以确定显着的预测因子。评估了两个计算器的受试者工作特征曲线下面积 (AUC) 和校准图。结果 172 名 (28.6%) 男性中检测出前列腺癌 (PCa)。活检呈阳性的独立预测因素包括高龄、PSA水平升高、移行区体积减小以及直肠指检结果异常。在内部和外部验证中，KPCRC 的 AUC 高于 PRC 3 和单独的 PSA。 KPCRC 的校准图在内部和外部验证方面显示出比其他模型更好的性能。应用 KPCRC 10% 的截止值意味着 602 名男性中的 251 名 (42%) 不会进行活检，172 名 PCa 病例中的 12 名 (7%) 不会被诊断出来。结论 KPCRC 提高了 PRC 3 和 PSA 检测在预测韩国人群患 PCa 风险方面的性能。这意味着亚洲人群需要自己的前列腺癌风险计算器。前列腺 72:721729, 2012。(C) 2011 Wiley periodicals, Inc.
BACKGROUND We developed a Korean Prostate Cancer Risk Calculator (KPCRC) for predicting the probability of a positive initial prostate biopsy using clinical and laboratory data from a Korean male population (http://pcrc.korea.ac.kr). We compared its performance to prostate-specific antigen (PSA) testing and the Prostate Risk Calculator 3 (PRC 3) based on data from the Dutch part of European Randomized Study of Screening for Prostate Cancer (ERSPC), which predicts biopsy results for previously unscreened men. METHODS Data were collected from 602 Korean men who were previously unscreened and underwent initial ten-core prostate biopsies. Multiple logistic regression analysis was performed to determine the significant predictors. Area under the receiver operating characteristic curve (AUC) and calibration plots of both calculators were evaluated. RESULTS Prostate cancer (PCa) was detected in 172 (28.6%) men. Independent predictors of a positive biopsy included advanced age, elevated PSA levels, reduced volume of the transition zone, and abnormal digital rectal examination findings. The AUC of the KPCRC was higher than the PRC 3 and PSA alone on internal and external validation. Calibration plots of the KPCRC showed better performance than the other models on internal and external validation. Applying a cut-off of 10% of KPCRC implied that 251 of the 602 men (42%) would not have been biopsied and that 12 of the 172 PCa cases (7%) would not have been diagnosed. CONCLUSIONS The KPCRC improves the performance of the PRC 3 and PSA testing in predicting Korean population's risk of PCa. It implies that Asian populations need their own risk calculators for PCa. Prostate 72:721729, 2012. (C) 2011 Wiley Periodicals, Inc.