The effect of supplemental parenteral nutrition on outcomes of necrotizing enterocolitis in premature, low birth weight neonates
The effect of supplemental parenteral nutrition on outcomes of necrotizing enterocolitis in premature, low birth weight neonates
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DOI：
10.1016/j.amjsurg.2015.08.004
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发表时间：
2015-12-01
影响因子：
3
通讯作者：
Olutoye, Oluyinka O.
中科院分区：
文献类型：
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作者：
Akinkuotu, Adesola C.;Nuthakki, Sushma;Olutoye, Oluyinka O.
背景：我们假设补充肠外营养(PN)可以减少坏死性小肠结肠炎(NEC)的手术需求和死亡率。方法：对2006年1月至2013年12月所有早产儿、低出生体重儿进行了单机构回顾。结果：114例早产儿、低出生体重儿确诊为NEC，其中59例(51.8%)需要手术治疗。外科NEC婴儿出生早(25.8+/-4.0vs27.8+/-3.3周，P=.005)，出生时体重(829+/-281vs938+/-271g，P=0.038)。外科和内科NEC患者的PN使用率差异无统计学意义(37.7%vs31.4%，P=.541)。在NEC发病时有PN的患者和没有PN的患者之间，出院时的死亡率没有统计学上的显著差异(31.4%比42.6%，P=.294)。结论：在这项单中心研究中，外科干预率和住院死亡率表明，在NEC发病时补充PN似乎不能显著改善预后。(C)2015 Elsevier Inc.保留所有权利。
BACKGROUND: We hypothesized that supplemental parenteral nutrition (PN) decreases the need for surgery and mortality associated with necrotizing enterocolitis (NEC).METHODS: Single institution retrospective review of all premature, low birth weight infants with NEC from January 2006 to December 2013 was conducted.RESULTS: NEC was identified in 114 premature, low birth weight infants, 59 (51.8%) of which required surgical management. Surgical NEC infants were born younger (25.8 +/- 4.0 vs 27.8 +/- 3.3 weeks, P = .005) and weighed less at birth (829 +/- 281 vs 938 +/- 271 g, P = .038) than those managed medically. There was no difference in the use of PN (37.7% vs 31.4%, P = .541) between surgical and medical NEC patients. There was no statistically significant difference in mortality at discharge between patients who had PN at NEC onset and those who did not (31.4% vs 42.6%, P = .294)CONCLUSION: In this single-center study, supplemental PN at NEC onset does not appear to significantly improve outcomes as demonstrated by rates of surgical intervention and in-hospital mortality. (C) 2015 Elsevier Inc. All rights reserved.