Beta-lactamase production diminishes the prophylactic efficacy of ampicillin and cefazolin in a guinea pig model of Staphylococcus aureus wound infection.
Beta-lactamase production diminishes the prophylactic efficacy of ampicillin and cefazolin in a guinea pig model of Staphylococcus aureus wound infection.
复制标题
在金黄色葡萄球菌伤口感染的豚鼠模型中，β-内酰胺酶的产生降低了氨苄青霉素和头孢唑啉的预防功效。
DOI：
10.1086/514231
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Kaiser,AB
中科院分区：
文献类型：
--
作者：
Kernodle,DS;Voladri,RK;Kaiser,AB
Clinical trials in surgery suggest that some failures of antibiotic prophylaxis are related to the in vivo degradation of β-lactams byStaphylococcus aureusβ-lactamase. To explore this issue further, isogeneic isolates ofS. aureusdiffering only in whether they contained the structural gene for type A staphylococcal β-lactamase were constructed and compared for their ability to establish an abscess in a guinea pig model. With ampicillin prophylaxis, the ID50was 870 cfu for the β-lactamase-negative isolate VK7114 and 240 cfu for the β-lactamase-producing isolate VK7115 (P< .001). Similarly, the ID50was greater for the β-lactamase-negative isolate when cefazolin prophylaxis was administered (599 vs. 128 cfu, VK7114 and VK7115;P< .001). In the setting of prophylaxis with β-lactamase-susceptible antibiotics, β-lactamase contributes to the pathogenesis ofS. aureuswound infections.
