Heterosexual behavior patterns and the spread of HIV/AIDS: The interacting effects of rate of partner change and sexual mixing
Heterosexual behavior patterns and the spread of HIV/AIDS: The interacting effects of rate of partner change and sexual mixing
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DOI：
10.1097/olq.0b013e31805ba84c
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发表时间：
2007-10-01
影响因子：
3.1
通讯作者：
Hertog, Sara
中科院分区：
文献类型：
--
作者：
Hertog, Sara
目的：本研究评估是否对人类免疫缺陷病毒（HIV）的流行曲线的性混合模式的影响是敏感的流行率的性伴侣的变化在population.Study设计：一个生物行为的宏观模拟模型，以评估相互作用的动态性伴侣的变化率和人口亚组之间的性混合模式。艾滋病毒的传播是模拟下2率的合作伙伴的变化情况下，在不同程度的discretativeness在性混合patterns.Results：与高利率的合作伙伴的变化，discretativeness在性混合往往会增加艾滋病毒流行的整体规模。然而，当相对较低的合作伙伴的变化率进行模拟，discretative混合产生一个较小的流行。这种模式是进一步影响潜在的性传播概率的HIV.Conclusions：艾滋病毒的性传播的各种决定因素中的每一个都不能被孤立地考虑。相反，在讨论艾滋病毒流行动态时，应考虑到这些决定因素的相互作用性质。
Objectives: This study evaluates whether the influence of sexual mixing patterns on the human immunodeficiency virus (HIV) epidemic curve is sensitive to the prevailing rates of sexual partner change in a population.Study Design: A biobehavioral macrosimulation model is employed to assess the interacting dynamics of the rates of sexual partner change and patterns of sexual mixing between population subgroups. HIV spread is simulated under 2 rates of partner change scenarios and under various degrees of assortativeness in sexual mixing patterns.Results: With high rates of partner change, disassortativeness in sexual mixing tends to increase the overall size of the HIV epidemic. However, when relatively low rates of partner change are simulated, disassortative mixing yields a smaller epidemic. This pattern is further influenced by the underlying sexual transmission probabilities of HIV.Conclusions: Each of the various determinants of the sexual spread of HIV must not be considered in isolation. Instead, the interactive nature of those determinants should be accounted for in discussions of HIV epidemic dynamics.