Wnt signaling in B and T lymphocytes
Wnt signaling in B and T lymphocytes
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DOI：
10.2741/1309
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发表时间：
2004-01-01
影响因子：
3.1
通讯作者：
Rudikoff, S
中科院分区：
文献类型：
--
作者：
Qiang, YW;Rudikoff, S
Wnt信号已被证明对正常的胚胎发育以及某些成年组织的生长调节至关重要。此外，Wnt通路的缺陷与许多人类癌症有关。然而，直到最近，wnt在免疫系统中的作用才得到重视。wnt现已被证明在B系和T系细胞的早期发育中发挥重要作用。目前的研究表明，这些细胞的增殖和/或存活与“典型”Wnt/ β -连环蛋白通路的激活有关。功能性Wnt信号似乎也发生在B末期（血浆）细胞中，此时“规范”和Wnt/RhoA通路都被激活。在此，我们回顾了目前对B细胞和T细胞发育中Wnt信号传导的理解，以及Wnt级联在淋巴样肿瘤中的潜在参与。
Wnt signaling has been shown to be critical for proper embryonic development as well as growth regulation of certain adult tissues. Defects in Wnt pathways have additionally been associated with a number of human cancers. However, it is only recently that a role for Wnts in the immune system has come to be appreciated. Wnts have now been shown to play significant roles in early stage development of both B and T lineage cells. Current studies suggest that proliferation and/or survival of these cells is associated with activation of the 'canonical' Wnt/beta-catenin pathway. Functional Wnt signaling appears to also occur in end stage B (plasma) cells where both the 'canonical' and the Wnt/RhoA pathways are activated. Herein, we review the current understanding of Wnt signaling in B and T cell development and the potential involvement of Wnt cascades in lymphoid neoplasia.