Computer-aided detection of amorphous calcifications
Computer-aided detection of amorphous calcifications
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DOI：
10.2214/ajr.184.3.01840887
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发表时间：
2005-03-01
影响因子：
5
通讯作者：
Baker, JA
中科院分区：
文献类型：
--
作者：
Soo, MS;Rosen, EL;Baker, JA
目标。计算机辅助检测(CAD)系统已成功地用于检测乳房X线片上的恶性钙化，灵敏度从86%到99%不等。无定形钙化是中等程度的微小模糊钙化的子集，有20%的可能性是恶性的，在乳房X光检查中经常被忽视。本研究的目的是确定一种商用CAD系统检测无定形钙化的灵敏度。材料和方法。一种商用的CAD系统评估了82名患者的乳房X光照片，其中85组经乳房X光检查发现并进行了组织学采样，无定形钙化(21例恶性，14例高危，50例良性)。确定了用于在双视乳房X光检查的至少一个图像上检测钙化的系统的灵敏度(病例灵敏度)和在每个单独的乳房X光图像上的钙化检测系统的灵敏度(图像灵敏度)。结果：在85例中，CAD系统检测到43例无定形钙化(病例敏感性，51%)，在146例乳房X光摄影图像中，59例(图像敏感性，40%)。组织学结果对恶性钙化的敏感性为57%，对高危钙化的敏感性为29%，对良性钙化的敏感性为54%。平均每个病例显示2.0个假阳性标记。结论：恶性无定形钙化的CAD敏感性明显低于先前报道的所有恶性钙化。使用CAD系统的乳腺影像放射科医生应该继续勤奋地寻找这些难以发现的病变。
OBJECTIVE. Computer-aided detection (CAD) systems have been used successfully to detect malignant calcifications on mammography, with sensitivities ranging from 86% to 99%. Amorphous calcifications are a subset of small indistinct calcifications of intermediate concern that have a 20% likelihood of being malignant and that are frequently overlooked on mammography. The purpose of our study was to determine the sensitivity of one commercially available CAD system for detecting amorphous calcifications.MATERIALS AND METHODS. A commercially available CAD system evaluated mammograms of 82 patients with 85 mammographically detected and histologically sampled groups of amorphous calcifications (21 malignant, 14 high risk, and 50 benign). The sensitivity of the system for detecting the calcifications on at least one image of the two-view mammographic examination (case sensitivity) and on each individual mammographic image (image sensitivity) was determined. Findings were correlated with results from large core needle biopsy or surgical excision in each case.RESULTS. The CAD system detected amorphous calcifications in 43 of 85 cases (case sensitivity, 51%) and in 59 of 146 mammographic images (image sensitivity, 40%). The case sensitivities by histologic outcome were 57% for malignant calcifications, 29% for high-risk calcifications, and 54% for benign calcifications. An average of 2.0 false-positive marks were displayed per case.CONCLUSION. The CAD sensitivity for malignant amorphous calcifications is markedly lower than previously reported for all malignant calcifications. Breast imaging radiologists who use CAD systems should continue to search diligently for these difficult-to-detect lesions.