Meningiomas: Role of vascular endothelial growth factor vascular permeability factor in angiogenesis and peritumoral edema
Meningiomas: Role of vascular endothelial growth factor vascular permeability factor in angiogenesis and peritumoral edema
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DOI：
10.1097/00006123-199705000-00027
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发表时间：
1997-05-01
期刊：
影响因子：
4.8
通讯作者：
Guha, A
中科院分区：
文献类型：
--
作者：
Provias, J;Claffey, K;Guha, A
目的：血管内皮生长因子(VEGF)/血管通透性因子(VPF)是一种强有力的血管生成生长因子，与多种肿瘤的血管生成和转移密切相关。血管内皮生长因子/血管内皮生长因子受体的激活对血管内皮细胞具有特异性的促有丝分裂作用，并增加其通透性。尽管已有大量文献报道血管内皮生长因子/血管内皮生长因子在人类星形细胞瘤中的作用，但对其在脑膜瘤中的潜在生物学作用知之甚少(S)。我们对脑膜瘤的兴趣源于这样的观察：一些脑膜瘤具有极强的血管性，偶尔还与相当程度的瘤周脑水肿有关，两者都可能与VEGF/VPF的生物学属性有关。方法：作为这一假说的第一个检验，我们研究了18例脑膜瘤中信使核糖核酸和蛋白水平的VEGF/VPF的表达，以及表达与病理特征、血管丰富和瘤周水肿程度的相关性。用内皮细胞标记物对相应的连续切片进行染色，获得微血管密度计数，并与血管内皮生长因子和血管内皮细胞生长因子的表达呈正相关(P=0.0005)。此外，术前CT扫描或磁共振成像显示有大量瘤周水肿的脑膜瘤，其VEGF/VPF的表达升高(P=0.05)。结论：VEGF/VPF可能在脑膜瘤的血管形成和瘤周水肿中起一定作用。
OBJECTIVE: Vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) is a potent angiogenic growth factor implicated in the tumor angiogenesis/metastasis of a number of human cancers. Activation of receptors for VEGF/VPF is specifically mitogenic to endothelial cells and increases their permeability. Although extensive literature exists regarding VEGF/VPF in human astrocytomas, little is known about its potential biological role(s) in meningiomas. Our interest in meningiomas was initiated by the observation that some meningiomas are extremely vascular and are occasionally associated with a considerable degree of peritumoral brain edema, both potentially related to the biological attributes of VEGF/VPF.METHODS: As a first test of this hypothesis, we examined a cohort of 18 meningiomas for expression of VEGF/VPF at the messenger ribonucleic acid and protein levels and correlated expression with pathological characteristics, vascularity, and degree of peritumoral edema.RESULTS: The majority of meningiomas expressed VEGF/VPF at both the messenger ribonucleic acid and protein levels. Corresponding serial sections were stained with an endothelial cell marker to obtain a microvascular density count, which positively correlated (P = 0.0005) with expression of VEGF/VPF. Furthermore, meningiomas with a large amount of peritumoral edema, as determined from the preoperative computed tomographic scans or magnetic resonance imaging scans, had elevated expression of VEGF/VPF (P = 0.05).CONCLUSION: These data suggest that VEGF/VPF may play a role in both meningioma vascularity and peritumoral edema.