A case of apathy due to frontotemporal dementia responsive to memantine.
A case of apathy due to frontotemporal dementia responsive to memantine.
复制标题
由于额颞叶痴呆对美金刚有反应而导致冷漠的一例。
DOI：
10.1080/13554794.2012.667120
复制
发表时间：
2013
期刊：
影响因子：
0.8
通讯作者：
Chow,TiffanyW
中科院分区：
文献类型：
--
作者：
Links,KiraA;Black,SandraE;Graff-Guerrero,Ariel;Wilson,AlanA;Houle,Sylvain;Pollock,BruceG;Chow,TiffanyW
目的：为了研究美金刚对冷漠的影响，冷漠是行为变异额颞叶痴呆（bvFTD）的常见症状。设计患者接受了美金刚的标签外试验，在基线、7周和6个月进行了行为清单和[18 F]氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）扫描。患者为一名66岁男性，bvFTD的主要表现为情感性，行为和认知冷漠。干预患者开始美金刚胺口服剂量为5毫克，每天早上和滴定5毫克，每周的维持剂量10 mg PO bid.ResultsInformants报告减少冷漠。小脑和小脑，都参与了显着网络，表现出改善metabolis.Conclusionfurther研究相关的影响美金刚对冷漠和显着网络bvFTD是必要的。
Objective: To study the effect of memantine on apathy, a common symptom of behavioral variant frontotemporal dementia (bvFTD).DesignThe patient underwent an off-label trial of memantine with behavioral inventories and [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) scans performed at baseline, 7 weeks and 6 months.Subject: The patient was a 66-year-old male whose main manifestation of bvFTD was affective, behavioral and cognitive apathy.InterventionThe patient began memantine at an oral dose of 5 mg per morning and titrated up by 5 mg per week to the maintenance dose of 10 mg PO bid.ResultsInformants reported reduction of the apathy. The insula and cerebellum, both involved in the salience network, showed improved metabolism.ConclusionFurther study to correlate the effects of memantine on apathy and the salience network in bvFTD are warranted.