Chlamydia trachomatis IgG3 seropositivity is associated with gastroschisis.
Chlamydia trachomatis IgG3 seropositivity is associated with gastroschisis.
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DOI：
10.1038/jp.2015.115
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Geisler WM
中科院分区：
文献类型：
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作者：
Feldkamp ML;Enioutina EY;Botto LD;Krikov S;Byrne JL;Geisler WM
To investigate the association between Chlamydia trachomatis (CT) infection seropositivity and gastroschisis. In this case-control study we enrolled pregnant women either prenatally diagnosed with gastroschisis (cases, n=33) or with a normal ultrasound (controls, n=66). Both groups attended the University of Utah's Maternal Fetal Medicine Diagnostic Center for their diagnostic ultrasound or because of a community obstetrician referral. Participants completed a structured interview on potential risk factors. Anti-CT IgG1 and IgG3 were measured by a CT elementary body ELISA. Median age at sexual debut was lower and reported sexual partner number higher in cases compared to controls. Risk factors for gastroschisis included having ≥3 sexual partners (OR=3.3, 95% CI 1.2, 9.4), change in partner from the previous pregnancy (OR=3.6, 95% CI 0.9, 13.9), and anti-CT IgG3 seropositivity (age-adjusted OR=3.9, 95% CI: 1.1, 13.2). Anti-CT IgG3 seropositivity was associated with greater than a 3-fold risk for gastroschisis.
