QUANTITATION OF HUMAN LEFT-VENTRICULAR MASS - AND VOLUME BY TWO-DIMENSIONAL ECHOCARDIOGRAPHY - INVITRO ANATOMIC VALIDATION
QUANTITATION OF HUMAN LEFT-VENTRICULAR MASS - AND VOLUME BY TWO-DIMENSIONAL ECHOCARDIOGRAPHY - INVITRO ANATOMIC VALIDATION
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DOI：
10.1161/01.cir.63.6.1398
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发表时间：
1981-01-01
期刊：
影响因子：
37.8
通讯作者：
REICHEK, N
中科院分区：
文献类型：
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作者：
HELAK, JW;REICHEK, N
对13例身体心脏(LV重量115~454g)进行了二维超声心动图(2-DE)左室切面面积、体积和心肌质量测定的可靠性评价。病理诊断：正常2例，冠状动脉病变合并梗塞和/或壁瘤5例，瓣膜病3例，心肌病2例，左室肥厚1例。将心脏分成6-24个短轴切片(No.=123)，在装满矿物油的油箱中成像，并对图像进行平面测量。校正后的照片和实际的LV重量作为参考标准。通过将合适的面积乘以截面厚度，得出了截面LV腔体积和心肌体积的估计值。心肌体积乘以心肌密度得到左室壁心肌质量。采用Simpson‘S法则和短轴面积-心尖长法计算左室腔总体积和心肌质量。从绝对值来看，2-DE低估了LV腔面积，但准确地估计了LV心肌面积。二维超声心动图与摄影标准测量的切面空洞面积(r=0.95)和体积(r=0.90)具有良好的相关性。Simpson‘’S法则(r=0.97)和面积长度(r=0.82，r=0.90，排除1例继发于广泛壁血栓的心脏畸形)估算的左心室腔总体积与参考标准有很好的相关性。左心室心肌面积与心肌摄影面积和二维超声心动图相关良好(r=0.89)，心肌重量摄影估计值与实际心肌重量呈良好相关(r=0.92和0.96)。用Simpson‘S法则和面积长度法计算的总左室质量具有较高的可靠性(r分别为0.93和0.92)。2-DE显然可以利用短轴辛普森S法则或面积-长度法和适当的回归校正方法提供可靠的左心室体积和质量的估计。面积长度法非常简单，便于临床应用。
The reliability of 2-dimensional echocardiographic (2-DE) quantitation of left ventricular (LV) section area, volume and myocardial mass was assessed in vitro in 13 postmortem human hearts (LV wt 115-454 g). The pathologic diagnoses included 2 normal, 5 coronary artery disease with infarction and/or aneurysm, 3 valvular heart disease, 2 cardiomyopathy and 1 left ventricular hypertrophy. Hearts were divided into 6-24 short-axis slices (no. = 123), imaged in a tank filled with mineral oil and the images planimetered. Calibrated photographs and actual LV weight served as reference standards. Estimates of section LV cavity volume and myocardial volume were derived by multiplying the appropriate area by section thickness. Section LV mass was obtained by multiplying the myocardial volume by myocardial density. Total LV cavity volume and myocardial mass were derived using Simpson''s rule and a short axis area-apical length method. In absolute terms 2-DE underestimated LV cavity area but accurately estimated LV myocardial area. Excellent correlations were obtained between 2-DE and photographic standards for section cavity area (r = 0.95) and volume (r = 0.90). Simpson''s rule (r = 0.97) and area-length (r = 0.82, r = 0.90, excluding 1 heart with a bizarrely shaped LV cavity secondary to extensive mural thrombus) estimates of total LV cavity volume correlated well with reference standards. Section LV myocardial area correlated well with photographic myocardial area (r = 0.89) and 2-DE and photographic estimates of section LV mass correlated well with actual LV wt (r = 0.92 and 0.96). Total LV mass obtained with Simpson''s rule or the area-length method was highly reliable (r = 0.93 and 0.92, respectively). 2-DE apparently can provide reliable estimates of LV volume and mass using the short-axis Simpson''s rule or area-length methods and appropriate regression corrections. The area-length method is simple enough to permit clinical application.