Assessment of depression severity with the PHQ-9 in cancer patients and in the general population
Assessment of depression severity with the PHQ-9 in cancer patients and in the general population
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DOI：
10.1186/s12888-016-0728-6
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发表时间：
2016-02-02
期刊：
影响因子：
4.4
通讯作者：
Schulte, Thomas
中科院分区：
文献类型：
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作者：
Hinz, Andreas;Mehnert, Anja;Schulte, Thomas
背景：患者健康问卷PHQ-9是临床研究中广泛使用的抑郁症筛查工具。本研究的第一个目的是在癌症患者的大样本中对PHQ-9进行心理测量测试。第二个目的是计算无偏估计的抑郁症负担的几个癌症组考虑到年龄和性别distributions.Methods：一个样本的2,059例癌症患者不同的诊断进行了检查，在这项研究6个月后出院的康复诊所。从一般人群中抽取的2，693人的代表性样本作为对照。预期的PHQ-9平均得分的一般人群样本，年龄和性别回归，计算，使公平比较不同群体的癌症patients.Results：虽然可靠性（克朗巴赫的α）的PHQ-9规模是好的（α>= 0.84），CFA的一维解决方案的拟合指数在患者的样本是不满意的。因子分析证实了两个因素。给出了15种癌症的PHQ-9平均评分，范围从4.0（前列腺）到8.2（甲状腺）。预期的平均分数（来自一般人群）和原始的癌症子样本的平均分数之间的差异报告，提供了一个更好的估计抑郁症burn.Conclusions：结果证实，PHQ-9在测试癌症患者的抑郁症。回归系数可用于在癌症组之间进行无偏比较，不仅适用于本研究。如果不考虑年龄和性别，睾丸癌和霍奇金淋巴瘤患者的负担被低估。
Background: The Patient Health Questionnaire PHQ-9 is a widely used instrument to screen for depression in clinical research. The first aim of this study was to psychometrically test the PHQ-9 in a large sample of cancer patients. The second aim was to calculate unbiased estimates of the depression burden for several cancer groups taking into account age and gender distributions.Methods: A sample of 2,059 cancer patients with varying diagnoses were examined in this study six months after discharge from a rehabilitation clinic. A representative sample of 2,693 people from the general population served as controls. Expected PHQ-9 mean scores of the general population sample, regressed on age and gender, were calculated to enable a fair comparison of different groups of cancer patients.Results: While the reliability (Cronbach's alpha) for the PHQ-9 scale was good (alpha >= 0.84), the CFA fit indices of the one-dimensional solution were unsatisfactory in the patients' sample. The factorial analysis confirmed two factors. PHQ-9 mean scores for 15 types of cancer are given, ranging from 4.0 (prostate) to 8.2 (thyroid gland). Differences between expected mean scores (derived from the general population) and raw mean scores of the cancer subsamples are reported that provide a better estimate of the depression burden.Conclusions: The results confirmed that the PHQ-9 performs well in testing depression in cancer patients. Regression coefficients can be used for performing unbiased comparisons among cancer groups, not only for this study. The burden of patients with testis cancer and Hodgkin lymphoma is underestimated when age and gender are not taken into account.