EFFECTS OF A NATURAL VOLUME OVERLOAD STATE (PREGNANCY) ON LEFT-VENTRICULAR PERFORMANCE IN NORMAL HUMAN SUBJECTS
EFFECTS OF A NATURAL VOLUME OVERLOAD STATE (PREGNANCY) ON LEFT-VENTRICULAR PERFORMANCE IN NORMAL HUMAN SUBJECTS
复制标题
DOI：
10.1161/01.cir.58.3.434
复制
发表时间：
1978-01-01
期刊：
影响因子：
37.8
通讯作者：
RESNIK, R
中科院分区：
文献类型：
--
作者：
KATZ, R;KARLINER, JS;RESNIK, R
为了评估自然容量超负荷状态（妊娠）对左心室功能的影响，在每三个月（TM）和产后4 - 12周记录超声心动图。心率从77.+-. 2（SEM，平均值的标准误差）至88. ±. 2次/分（TM 1对TM 3，P <0.01），下降至69 ± 0.5次/分。2.0与TM3比较，P <0.05。尽管有这些变化，舒张末期尺寸从46.3. ±. 0.7至50.7.+-。0.7 TM 1对TM 3，P <0.01，产后下降至47.5 ± 0.01。0.7 mm（P <0.01）。计算的每搏输出量和心脏指数相应改变，但射血分数、缩短分数百分比和内径缩短的平均标准化率无显著改变。左室壁质量在妊娠期增加，但在TM 3和产后之间减少（162. ±. 8.3对比143.+-。6.2 g，P <0.05）。左室后壁厚度与左室半径的比值从0.32 ± 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000 0.01至0.29.+-. 0.01（TM 1与TM 3，P <0.0 5），提示进行性离心性左室扩大。正常人的暂时性容量超负荷状态导致血流动力学调整，通常在心脏失代偿中观察到（心率和大小增加）。左心室功能虽然没有增强，但保存良好，导致分钟输出量增加。尽管左心室进行性增大，但左心室的缩短特征仍未受损。
To assess the effects of a natural volume overload state (pregnancy) on left ventricular function echocardiograms were recorded each trimester (TM) and 4-12 wk postpartum. Heart rate increased from 77 .+-. 2 (SEM, standard error of the mean) to 88 .+-. 2 beats/min (TM 1 vs. TM 3, P < 0.01) and declined to 69 .+-. 2.0 beats/min postpartum (P < 0.05 vs. TM 3). Despite these changes, end-diastolic dimension increased from 46.3 .+-. 0.7 to 50.7 .+-. 0.7 mm (TM 1 vs. TM 3, P < 0.01) and decreased postpartum to 47.5 .+-. 0.7 mm (P < 0.01 vs. TM 3). Calculated stroke volume and cardiac index changed correspondingly, but ejection fraction, percent of fractional shortening and mean normalized rate of internal diameter shortening were not significantly altered. Left ventricular wall mass increased during gestation but decreased between TM 3 and postpartum (162 .+-. 8.3 vs. 143 .+-. 6.2 g, P < 0.05). The ratio of posterior wall thickness to left ventricular radius decreased from 0.32 .+-. 0.01 to 0.29 .+-. 0.01 (TM 1 vs. TM 3, P < 0.05), indicating progressive eccentric left ventricular enlargement. A temporary volume overload state in normal humans results in hemodynamic adjustments often observed in cardiac decompensation (increased heart rate and size). Left ventricular function, although not augmented, is well-preserved, leading to an increase in minute output. Despite progressive left ventricular enlargement the shortening characteristics of the left ventricle remain unimpaired.