Novel and diagnostically applicable information from optical waveform analysis of blood coagulation in disseminated intravascular coagulation
Novel and diagnostically applicable information from optical waveform analysis of blood coagulation in disseminated intravascular coagulation
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DOI：
10.1046/j.1365-2141.1997.1062972.x
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发表时间：
1997-07-01
影响因子：
6.5
通讯作者：
Toh, CH
中科院分区：
文献类型：
--
作者：
Downey, C;Kazmi, R;Toh, CH
透射率波形是指在新一代自动凝血分析仪MDA-180上进行的标准凝血测试中，凝块形成过程中产生的光学剖面。在弥散性血管内凝血患者中，活化的部分凝血活酶时间和凝血酶时间波形均可见特征性的异常“双相改变”。波形上初始坡度的睡眠增加与临床恶化和暴发性进展相关。尽管双期表现的机制仍有待阐明，但其识别为诊断实验室提供了一种简单、快速和可靠的弥散性血管内凝血检测方法，可以帮助临床医生采取紧急和适当的治疗干预措施。
Transmittance waveform is the term applied to the optical profile generated from the process of clot formation on standard coagulation tests run on the MDA-180, a new-generation automated coagulation analyser. In patients with disseminated intravascular coagulation, a characteristically abnormal 'biphasic change' is seen on both the activated partial thromboplastin time and thrombin time waveforms. Increasing sleepness of the initial slope on the waveforms correlates with clinical deterioration and fulminant progression. Although the mechanism underlying the biphasic appearance remains to be elucidated, its identification provides the diagnostic laboratory with a simple, rapid and robust assay for disseminated intravascular coagulation that can help the clinician with urgent and appropriate therapeutic interventions.