Recent trends in the tuning of polymersomes' membrane properties
Recent trends in the tuning of polymersomes' membrane properties
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DOI：
10.1140/epje/i2011-11014-y
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发表时间：
2011-02-01
影响因子：
1.8
通讯作者：
Lecommandoux, S.
中科院分区：
文献类型：
--
作者：
Le Meins, J. -F.;Sandre, O.;Lecommandoux, S.
“聚合物囊泡”是由嵌段共聚物自组装制成的囊泡结构。这种结构对不同的应用（例如微米或纳米反应器、药物释放）表现出极大的兴趣，或者可以简单地用作理解基本生物机制的工具。聚合物囊泡在此类应用中的使用与其膜特性的控制和调节方式密切相关，可以通过构成块的精确分子设计或通过在膜内添加特定成分（配方方法）来控制和调节。首先将简要回顾自九十年代末以来通过“线圈线圈”嵌段共聚物的自组装获得的聚合物囊泡的典型膜性质，并将其与其脂质类似物（称为脂质体）的膜性质进行比较。因此，详细介绍了利用大分子工程或制剂来调节其渗透性、机械性能或释放负载药物的能力的不同方法。总之，本文介绍了调节聚合物囊泡特性和系统的最新进展，这些进展似乎非常有前景，特别是对于生物医学应用或复杂和仿生结构的开发。
"Polymersomes" are vesicular structures made from the self-assembly of block copolymers. Such structures present outstanding interest for different applications such as micro- or nano-reactor, drug release or can simply be used as tool for understanding basic biological mechanisms. The use of polymersomes in such applications is strongly related to the way their membrane properties are controlled and tuned either by a precise molecular design of the constituting block or by addition of specific components inside the membrane (formulation approaches). Typical membrane properties of polymersomes obtained from the self-assembly of "coil coil" block copolymer since the end of the nineties will be first briefly reviewed and compared to those of their lipidic analogues, named liposomes. Therefore the different approaches able to modulate their permeability, mechanical properties or ability to release loaded drugs, using macromolecular engineering or formulations, are detailed. To conclude, the most recent advances to modulate the polymersomes' properties and systems that appear very promising especially for biomedical application or for the development of complex and bio-mimetic structures are presented.