Association between arsenic exposure and a measure of subclinical sensory neuropathy in Bangladesh
Association between arsenic exposure and a measure of subclinical sensory neuropathy in Bangladesh
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DOI：
10.1097/01.jom.0000169089.54549.db
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发表时间：
2005-08-01
影响因子：
3.2
通讯作者：
Graziano, JH
中科院分区：
文献类型：
--
作者：
Hafeman, DM;Ahsan, H;Graziano, JH
目的：我们研究了孟加拉国砷暴露与周围神经病变之间的关系，孟加拉国的人口长期暴露于饮用水中的砷。方法：我们对来自一个更大队列的137名受试者进行了一项横断面研究。暴露措施包括个人水砷浓度，累积砷指数，尿砷浓度在两个时间点（2001年和2003年）。主要结果测量是振动触觉阈值升高，由振动灵敏度测试仪（Vibratron II）测量。结果：砷暴露。与脚趾振动阈值（TVT）升高相关。具体而言，调整年龄和性别后，累积砷指数和尿砷（2001年）均与TVT升高显著相关（分别为P = 0.02和P = 0.009）。结论：通过累积和尿量测量，砷暴露增加与亚临床感觉神经病变的证据相关。.
Objectives: We examined the association between arsenic exposure and peripheral neuropathy in Bangladesh, where the population has been chronically exposed to arsenic in drinking water. Methods: We conducted a cross-sectional study of 137 subjects derived from a larger cohort. Exposure measures included individual water arsenic concentration, cumulative arsenic index, and urinary arsenic concentration taken at two time points (2001 and 2003). The primary outcome measurement was elevated vibrotactile threshold, as measured by a vibration sensitivity tester (Vibratron II). Results: Arsenic exposure. was associated with elevated toe vibration threshold (TVT). Specifically, cumulative arsenic index and urinary arsenic (2001) were both significantly associated with elevated TVT (P = 0.02 and P = 0.009, respectively) after adjustment for age and gender. Conclusions: Increased arsenic exposure, as measured by both cumulative and urinary measures, was associated with evidence of subclinical sensory neuropathy. .