Cancer stem cells: impact, heterogeneity, and uncertainty.
Cancer stem cells: impact, heterogeneity, and uncertainty.
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DOI：
10.1016/j.ccr.2012.03.003
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发表时间：
2012-03-20
期刊：
影响因子：
50.3
通讯作者：
Morrison SJ
中科院分区：
文献类型：
--
作者：
Magee JA;Piskounova E;Morrison SJ
致瘤性癌症干细胞向非致瘤性癌细胞的分化赋予某些癌症异质性，超出了克隆进化或环境差异所解释的异质性。在这种癌症中，致瘤细胞和非致瘤细胞之间的功能差异影响对治疗的反应和预后。然而，由于对癌症干细胞标志物的稳健性以及现有检测方法低估致瘤细胞频率的程度的质疑，该模型是否适用于许多或少数癌症仍不确定。在具有快速遗传变化、细胞状态的可逆变化或患者之间的生物变异性的癌症中，干细胞模型可能不容易测试。
The differentiation of tumorigenic cancer stem cells into non-tumorigenic cancer cells confers heterogeneity to some cancers beyond that explained by clonal evolution or environmental differences. In such cancers, functional differences between tumorigenic and non-tumorigenic cells influence response to therapy and prognosis. However, it remains uncertain whether the model applies to many, or few, cancers due to questions about the robustness of cancer stem cell markers and the extent to which existing assays underestimate the frequency of tumorigenic cells. In cancers with rapid genetic change, reversible changes in cell states, or biological variability among patients the stem cell model may not be readily testable.