The murine homologues of the Huntington disease gene (Hdh) and the alpha-adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3.
The murine homologues of the Huntington disease gene (Hdh) and the alpha-adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3.
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DOI：
10.1006/geno.1994.1361
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发表时间：
1994-07
期刊：
影响因子：
4.4
通讯作者：
J. Nasir;B. Lin;M. Bucan;T. Koizumi;J. Nadeau;M. Hayden
中科院分区：
文献类型：
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作者：
J. Nasir;B. Lin;M. Bucan;T. Koizumi;J. Nadeau;M. Hayden
亨廷顿病(HD)是一种与新基因(IT15)相关的常染色体显性遗传性神经退行性疾病。最近，我们报道了IT15的小鼠同源基因hdh的克隆。在这里，利用种间回交，我们定位了HDH和小鼠的人类α-内收蛋白(Add1)的同源基因，这是一种膜相关的细胞骨架蛋白基因。这两个基因都定位在小鼠5号染色体上与祖先染色体重排相关的区域的相同位置，并且分别与D4S43、D4S115和D4S62的小鼠同源物D5H4S43、D5H4S115和D5H4S62没有重组。对人类、小鼠和其他哺乳动物物种的进一步图谱研究应该会揭示在哺乳动物进化过程中影响这一染色体片段的重排的性质。
Huntington disease (HD) is a severe autosomal dominant neurodegenerative disorder associated with a novel gene (IT15). Recently, we reported the cloning of Hdh, the murine homologue of IT15. Here, using an interspecific backcross, we have mapped both Hdh and the mouse homologue of human alpha-adducin (Add1), a membrane-associated cytoskeletal protein gene. Both of these genes map in the same position on mouse chromosome 5 in a region associated with ancestral chromosomal rearrangements and show no recombination with D5H4S43, D5H4S115, and D5H4S62, the murine homologues of D4S43, D4S115, and D4S62, respectively. Further mapping studies of humans, mice, and other mammalian species should reveal the nature of the rearrangements affecting this chromosomal segment during mammalian evolution.