Evidence that sympathetic preganglionic neurones are arranged in target‐specific columns in the thoracic spinal cord of the rat
Evidence that sympathetic preganglionic neurones are arranged in target‐specific columns in the thoracic spinal cord of the rat
复制标题
证据表明交感神经节前神经元排列在大鼠胸脊髓的目标特异性柱中
DOI：
--
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
J. Coote
中科院分区：
文献类型：
--
作者：
S. Pyner;J. Coote
人们认识到，不同靶特异性交感节前神经元的选择性激活形成许多自主反应的基础。其解剖学基础可能是这些神经元在脊髓核中的空间排列。本研究测试这种可能性在大鼠中确定的位置在单一的动物的三个不同的组交感神经节前神经元，一组投射到上级颈神经节，另一个星状神经节和肾上腺髓质。交感神经节前神经元的这些目标，同时标记的荧光染料，荧光金，固蓝，或二脒基黄。神经元的数量和一般形态与以前的描述相似，它们分布在四个亚核中，即中间外侧核主部、中间外侧核索部、棘间核和棘间核室管膜旁部。结果表明，所有三组神经元的代表更内侧交感神经核，但在中间灰质的外侧边缘的核中，三组神经元中的每一个都占据了一个离散的位置。肾上腺髓质交感节前神经元位于外侧，上级颈神经节交感节前神经元位于内侧，星状神经节交感节前神经元位于中间。一些交感神经节前神经元的双重标记后，染料注射到上级颈和星状神经节，从而表明，他们投射到这两个神经节。它的结论是，有人口的交感神经节前神经元排列在水平列，只发送轴突预测的上级颈，星状神经节，或肾上腺髓质，分别，因此为每个结构的目标指定。这种安排可能是重要的，在理解自主效应器的选择性激活，不同类型的行为的一个特征。© 1994 Wiley‐利斯公司
It is recognised that selective activation of different target‐specific sympathetic preganglionic neurones forms the basis of many autonomic responses. The anatomical basis for this could be the spatial arrangement of these neurones in the spinal cord nuclei. The present study tested this possibility in the rat by determining the location in single animals of three distinct groups of sympathetic preganglionic neurones, one group projecting to the superior cervical ganglion, another to the stellate ganglion and one to the adrenal medulla. Sympathetic preganglionic neurones to each of these targets were simultaneously labeled with fluorescent dyes, either Fluorogold, Fast Blue, or Diamidino Yellow. The numbers and general morphology of the neurones were similar to previous descriptions, and they were distributed in four subnuclei, the nucleus intermediolateralis pars principalis, the nucleus intermediolateralis pars funiculus, the nucleus intercalatus spinalis, and the nucleus intercalatus spinalis pars paraependymalis. It was shown that all three groups of neurones were represented in the more medial sympathetic nuclei, but in the nuclei at the lateral border of the intermediate grey matter each one of the three groups of neurones occupied a discrete location. Adrenal medullary sympathetic preganglionic neurones occupied a lateral aspect, the superior cervical ganglion sympathetic preganglionic neurones a medial aspect, and the stellate ganglion sympathetic preganglionic neurones a space between. Some sympathetic preganglionic neurones were double labeled after dye injections into the superior cervical and stellate ganglion thus indicating that they projected to both ganglia. It is concluded that there are populations of sympathetic preganglionic neurones arranged in horizontal columns which only send axonal projections to the superior cervical, stellate ganglia, or adrenal medulla, respectively, and hence are target specified for each structure. This arrangement is likely to be of importance in understanding selective activation of autonomic effectors, a feature of different types of behaviour. © 1994 Wiley‐Liss, Inc.