Simultaneous presence of DDT and pyrethroid residues in human breast milk from a malaria endemic area in South Africa
Simultaneous presence of DDT and pyrethroid residues in human breast milk from a malaria endemic area in South Africa
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DOI：
10.1016/j.envpol.2006.02.002
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发表时间：
2006-12-01
影响因子：
8.9
通讯作者：
Meinhardt, H. M.
中科院分区：
文献类型：
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作者：
Bouwman, H.;Sereda, B.;Meinhardt, H. M.
在南非夸祖鲁-纳塔尔省三个城镇的152份母乳样本中测定了滴滴涕和拟除虫菊酯，其中一个城镇不需要滴滴涕来控制疟疾。所有化合物都存在于母乳中。一个城镇初产妇的Sigma DDT全脂乳平均含量最高（238.23 μ g/l），同一城镇的多胎婴儿的氯菊酯平均含量最高（14.51 μ g/l）、氟氯菊酯（41.74 μ g/l）、氯氰菊酯（4.24 μ g/l）、溴氰菊酯（8.39 μ g/l）和Sigma拟除虫菊酯（31.5 μ g/l），最可能来自农业。只有一个城镇的婴儿超过了滴滴涕的建议摄入量，但没有超过拟除虫菊酯的建议摄入量。由于DDT的ADI最近从20 μ g/kg/bw降至10 μ g/kg/bw，我们建议关注这方面的问题。因此，由于存在四种不同的拟除虫菊酯和滴滴涕，我们提出了基于毒物相互作用的关注。然而，在当前条件下，母乳喂养仍然是安全的。(c) 2006 Elsevier Ltd.版权所有。
DDT and pyrethroids were determined in 152 breast-milk samples from three towns in KwaZulu-Natal, South Africa, one of which had no need for DDT for malaria control. All compounds were found present in breast milk. Primiparae from one town had the highest mean Sigma DDT whole milk levels (238.23 mu g/l), and multiparae from the same town had the highest means for permethrin (14.51 mu g/l), cyfluthrin (41.74 mu g/l), cypermethrin (4.24 mu g/l), deltamethrim (8.39 mu g/l), and Sigma pyrethroid (31.5 mu g/l), most likely derived from agriculture. The ADI for DDT was only exceeded by infants from one town, but the ADI for pyrethroids was not exceeded. Since the ADI for DDT was recently reduced from 20 to 10 mu g/kg/bw, we suggest that this aspect be treated with concern. We therefore raise a concern based on toxicant interactions, due to the presence of four different pyrethroids and DDT. Breastfeeding however, remains safe under prevailing conditions. (c) 2006 Elsevier Ltd. All rights reserved.