3D reconstruction techniques of human coronary bifurcations for shear stress computations
3D reconstruction techniques of human coronary bifurcations for shear stress computations
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DOI：
10.1016/j.jbiomech.2013.10.021
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发表时间：
2014-01-03
影响因子：
2.4
通讯作者：
Wentzel, Jolanda J.
中科院分区：
文献类型：
--
作者：
Gijsen, Frank J. H.;Schuurbiers, Johan C. H.;Wentzel, Jolanda J.
背景：人冠状动脉分叉处斑块成分的异质性与血流诱导的切应力有关。剪切应力通常通过结合3D管腔数据和计算流体动力学（CFD）来确定。我们研究了两个新的程序，以产生三维管腔重建冠状动脉分叉的剪切stresscalculation.Methods：我们成像10例多层计算机断层扫描（MSCT）和血管内超声（IVUS）。主分支的三维重建基于MSCT和IVUS的融合。侧分支近端分别采用IVUS数据和MSCT数据进行重建，得到两种不同的分叉区重建方法。侧分支的远端部分仅基于MSCT数据。将重建的管腔与CFD相结合以确定剪切应力。低和高剪切应力区域的定义和剪切应力模式在分叉regions.Results：三维冠状动脉分叉重建程序成功地产生。两种重建程序的分叉区域的几何特征没有显示出明显的差异。剪切应力图显示出定性一致性，并且低剪切应力区域和高剪切应力区域的大小相似，平均剪切应力值相同。结论：仅利用MSCT数据重建侧分支是研究分支区切应力和壁厚的一种有效方法。重建过程可用于进一步研究冠状动脉分叉处剪切应力对动脉粥样硬化的影响。(C)2013爱思唯尔有限公司保留所有权利。
Background: Heterogeneity in plaque composition in human coronary artery bifurcations is associated with blood flow induced shear stress. Shear stress is generally determined by combing 3D lumen data and computational fluid dynamics (CFD). We investigated two new procedures to generate 3D lumen reconstructions of coronary artery bifurcations for shear stress computations.Methods: We imaged 10 patients with multislice computer tomography (MSCT) and intravascular ultrasound (IVUS). The 3D reconstruction of the main branch was based on the fusion of MSCT and IVUS. The proximal part of side branch was reconstructed using IVUS data or MSCT data, resulting in two different reconstructions of the bifurcation region. The distal part of the side branch was based on MSCT data alone. The reconstructed lumen was combined with CFD to determine the shear stress. Low and high shear stress regions were defined and shear stress patterns in the bifurcation regions were investigated.Results: The 3D coronary bifurcations were successfully generated with both reconstruction procedures. The geometrical features of the bifurcation region for the two reconstruction procedures did not reveal appreciable differences. The shear stress maps showed a qualitative agreement, and the low and high shear stress regions were similar in size and average shear stress values were identical. The low and high shear stress regions showed an overlap of approximately 75%.Conclusion: Reconstruction of the side branch with MSCT data alone is an adequate technique to study shear stress and wall thickness in the bifurcation region. The reconstruction procedure can be applied to further investigate the effect of shear stress on atherosclerosis in coronary bifurcations. (C) 2013 Elsevier Ltd. All rights reserved.