Haustral boundary contractions in the proximal 3-taeniated rabbit colon
Haustral boundary contractions in the proximal 3-taeniated rabbit colon
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DOI：
10.1152/ajpgi.00171.2015
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发表时间：
2016-02-01
影响因子：
4.5
通讯作者：
Huizinga, Jan D.
中科院分区：
文献类型：
--
作者：
Chen, Ji-Hong;Yang, Zixian;Huizinga, Jan D.
兔近端结肠的结构与人类结肠相似。我们的目标是使用视频记录的时空映射来研究不同节律运动模式的相互作用，重点关注产生包的包边界收缩。豪斯特拉边界收缩被视为高度有节奏的圆周环收缩，缓慢地穿过近端结肠，优先但不排他地沿肛门方向，以类似于每分钟 0.5 个周期的速度传播；它们被神经传导阻滞剂消除了。当多个袋边界收缩向相反方向传播时，它们一相遇就会相互湮灭。波纹、肌源性传播环收缩类似于每分钟 9 个周期，诱导腹肌褶皱的折叠和展开，产生收缩活动的无政府主义外观，在三个带间区域具有不同的模式。波纹活动的两个特征很突出：传播方向的频繁变化和位错的发生，显示远端结肠中固有频率最高的频率梯度。胃口边界收缩在波纹频率上呈现出开/关/开/关模式，并且结肠任意点的收缩幅度呈现出渐强和渐弱。因此，袋边界收缩是由两个起搏器活动的相互作用形成的，这两个起搏器活动被假设是通过来自肌间神经丛和肌下神经丛的卡哈尔间质细胞的起搏器活动的相位振幅耦合而发生的。视频证据显示了袋褶皱在塑造袋内收缩活动中发挥的独特作用。毒蕈碱剂不仅可以增强收缩力，还可以消除一种收缩力，同时诱导另一种神经依赖性运动模式。
The rabbit proximal colon is similar in structure to the human colon. Our objective was to study interactions of different rhythmic motor patterns focusing on haustral boundary contractions, which create the haustra, using spatiotemporal mapping of video recordings. Haustral boundary contractions were seen as highly rhythmic circumferential ring contractions that propagated slowly across the proximal colon, preferentially but not exclusively in the anal direction, at similar to 0.5 cycles per minute; they were abolished by nerve conduction blockers. When multiple haustral boundary contractions propagated in the opposite direction, they annihilated each other upon encounter. Ripples, myogenic propagating ring contractions at similar to 9 cycles per min, induced folding and unfolding of haustral muscle folds, creating an anarchic appearance of contractile activity, with different patterns in the three intertaenial regions. Two features of ripple activity were prominent: frequent changes in propagation direction and the occurrence of dislocations showing a frequency gradient with the highest intrinsic frequency in the distal colon. The haustral boundary contractions showed an on/off/on/off pattern at the ripple frequency, and the contraction amplitude at any point of the colon showed waxing and waning. The haustral boundary contractions are therefore shaped by interaction of two pacemaker activities hypothesized to occur through phase-amplitude coupling of pacemaker activities from interstitial cells of Cajal of the myenteric plexus and of the submuscular plexus. Video evidence shows the unique role haustral folds play in shaping contractile activity within the haustra. Muscarinic agents not only enhance the force of contraction, they can eliminate one and at the same time induce another neurally dependent motor pattern.