Spheroid Mesenchymal Stem Cells and Mesenchymal Stem Cell-Derived Microvesicles: Two Potential Therapeutic Strategies.
Spheroid Mesenchymal Stem Cells and Mesenchymal Stem Cell-Derived Microvesicles: Two Potential Therapeutic Strategies.
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球状间充质干细胞和间充质干细胞衍生的微泡：两种潜在的治疗策略。
DOI：
10.1089/scd.2015.0278
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发表时间：
2016-02
影响因子：
4
通讯作者：
Jiang, Bing
中科院分区：
文献类型：
--
作者：
Xie, Lili;Mao, Mao;Zhou, Liang;Jiang, Bing
间充质干细胞（Mesenchymal stem cells，MSCs）由于具有分化为其他细胞系、分泌旁分泌因子、调节炎症和免疫的能力以及治疗退行性疾病的有效性而引起了世界范围内科学家和临床医生的关注。最近的研究表明，与传统的二维（2D）培养相比，当在球体中培养时，MSC具有更大的分化能力，并且增加了抗炎和免疫调节能力。此外，球状体MSC可用于临床相关制造平台中的规模化生产。微泡（Microvesicles，MV）是一种小的膜泡，可以将蛋白质、遗传物质和脂质转移到细胞中。来源于骨髓间充质干细胞的微血管（MSC-MVs）不仅是一种有效的分子信息传递载体，而且在一系列组织修复和抗肿瘤实验中也是有效的。因此，球形MSC和MSC-MV在实验和临床应用中具有巨大的潜力。本文就球形MSCs和MSC-MVs的特性、治疗应用和潜在的临床转化机会进行综述。
Mesenchymal stem cells (MSCs) have drawn worldwide attention of scientists and clinicians due to their ability to differentiate into other cell lineages, secrete paracrine factors, modulate inflammation and immunity, and also due to the effectiveness of MSCs in treating degenerative diseases. Recent studies have shown that, when cultured in spheroids, MSCs have greater differentiation ability, and increased anti-inflammatory and immunomodulatory capacities compared with traditional two-dimensional (2D) cultures. Furthermore, spheroid MSCs can be used on scale-up productions in clinically relevant manufacturing platforms. Microvesicles (MVs) are small membranous vesicles that can transfer proteins, genetic materials, and lipids to cells. MVs derived from MSCs (MSC-MVs) are not only emerging as potent transfer agents for molecular information, but also are effective in a series of tissue repair and anti-tumor experiments. Therefore, both spheroid MSCs and MSC-MVs have great potential in experimental and clinical applications. In this review, the characteristics, therapeutic applications and potential clinical translational opportunities of spheroid MSCs and MSC-MVs were discussed.
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影响因子：
5.8
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
3.3
作者：
Skiles ML;Hanna B;Rucker L;Tipton A;Brougham-Cook A;Jabbarzadeh E;Blanchette JO
通讯作者：
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