Role of HGF-Loaded Nanoparticles in Treating Rat Acute Hepatic Failure
Role of HGF-Loaded Nanoparticles in Treating Rat Acute Hepatic Failure
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负载 HGF 的纳米颗粒在治疗大鼠急性肝衰竭中的作用
DOI：
10.5754/hge11242
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发表时间：
2013-10-01
影响因子：
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通讯作者：
Li, Zhi-Feng
中科院分区：
文献类型：
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作者：
Chang, Ren-An;Chen, Zhong;Li, Zhi-Feng
背景/目标：探讨载肝细胞生长因子（HGF）聚乳酸-O-羧甲基壳聚糖（PLA-O-CMC）纳米粒在肝细胞移植（HCT）治疗大鼠急性肝功能衰竭（ALF）中的作用。研究方法：将5ml分别经常规培养（I组）、PLA-O-CMC纳米颗粒（II组）和载HGF的PLA-O-CMC纳米颗粒（III组）处理的肝细胞移植到ALE大鼠的腹腔内。IV组除每天静脉注射10 μ g HGF外，其余处理同II组，共7天。结果：HCT后第14天存活率Ⅲ、Ⅳ、Ⅱ组均高于Ⅴ组（p
Background/Aims: To explore the role of hepatocyte growth factor (HGF)-loaded polylactic acid-O-carboxymethylated chitosan (PLA-O-CMC) nanoparticles in hepatocyte transplantation (HCT) for treating rat acute liver failure (ALF). Methods: Five milliliters of hepatocytes respectively treated with conventional culture (group I), PLA-O-CMC nanoparticles (group II) and HGF-loaded PLA-O-CMC nanopartides (group III) were transplanted into the abdominal cavities of rat with ALE In group IV, rats were treated as group II except intravenous 10 mu g of HGF daily for 7 days, and in group V, rats were given intraperitoneal RPMI-1640. Results: The survival rate on the 14th day after HCT was higher in groups III, IV, and II than in group V (p