DRUG TARGETING WITH NANOPARTICLES
DRUG TARGETING WITH NANOPARTICLES
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DOI：
10.1007/bf03188928
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发表时间：
1994-07-01
影响因子：
1.9
通讯作者：
KREUTER, J
中科院分区：
文献类型：
--
作者：
KREUTER, J
纳米颗粒是胶体聚合物颗粒（尺寸< 1000纳米），通过吸附、掺入或化学结合将药物结合在其上。经静脉注射后，它们通常分布到网状内皮系统的器官（肝、脾、肺、骨髓）。然而，它们的体内分布可以通过表面活性剂或生理成分如血清补体因子的涂覆而改变。讨论了这些涂层对体分布的影响以及改变这种分布的可能机制。不同涂层的纳米颗粒可用于靶向结合药物到肿瘤、大脑和身体的炎症区域。
Nanoparticles are colloidal polymeric particles (size < 1000 nm) to which drugs are bound by sorption, incorporation, or chemical binding. After intravenous injection they normally distribute into the organs of the reticuloendothelial system (liver, spleen, lungs, bone marrow). However, their body distribution can be altered by coating with surfactants or with physiological components such as serum complement factors. The influence of these coatings on the body distribution and possible mechanisms for the alteration of this distribution are discussed. Differently coated nanoparticles can be used for the targeting of bound drugs to tumors, to the brain, and to inflamed areas in the body.