Influence of mercurial sulfhydryl agents on aqueous outflow pathways in enucleated eyes.
Influence of mercurial sulfhydryl agents on aqueous outflow pathways in enucleated eyes.
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DOI：
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发表时间：
1984-03
影响因子：
4.4
通讯作者：
T. Freddo;M. Patterson;D. R. Scott;D. Epstein
中科院分区：
文献类型：
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作者：
T. Freddo;M. Patterson;D. R. Scott;D. Epstein
去核小牛和灵长类动物的眼睛用对氯汞苯磺酸盐（PCMBS）或对氯汞苯（PCMB）进行灌注。两者都会导致房水流出减少，而这并不是由于小梁细胞糖酵解受到抑制所致。对 PCMBS 处理的灵长类动物眼睛的形态学研究表明，房水流出量的减少是由于小梁网，特别是近小管结缔组织中细胞肿胀的结果。这些发现表明，细胞体积的变化可能会影响小梁的流出阻力，并且汞敏感的膜巯基可能参与房水流出的调节。
Enucleated calf and primate eyes were perfused with either p-chloromercuribenzene sulfonate (PCMBS) or p-chloromercuribenzene (PCMB). Both caused a decrease in aqueous outflow that did not result from inhibition of glycolysis in trabecular cells. Morphologic studies of PCMBS-treated primate eyes suggested that the reduction in aqueous outflow occurred as the result of cellular swelling in the trabecular meshwork and, particularly, in the juxtacanalicular connective tissue. These findings suggest that changes in cell volume may influence trabecular outflow resistance and that mercurial-sensitive membrane sulfhydryl groups could participate in the regulation of aqueous outflow.