Synthetic Progress toward Azadirachtins. 2. Enantio- and Diastereoselective Synthesis of the Right-Wing Fragment of 11-epi-Azadirachtin I
Synthetic Progress toward Azadirachtins. 2. Enantio- and Diastereoselective Synthesis of the Right-Wing Fragment of 11-epi-Azadirachtin I
复制标题
印楝素的合成进展。
DOI：
10.1021/acs.orglett.5b00831
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发表时间：
2015
期刊：
影响因子：
5.2
通讯作者：
Yang Zhen
中科院分区：
文献类型：
--
作者：
Tan Ceheng;Chen Wei;Mu Xinpeng;Chen Qi;Gong Jianxian;Luo Tuoping;Yang Zhen
研究了烯丙基溴化锌、乙醛酸硅酯和β-内酯的立体选择性三组分偶联反应。这已成功地应用于对映体和非对映体选择性合成的完全功能化的呋喃部分印楝素。
A stereoselective three-component coupling reaction of allylzinc bromide, silyl glyoxylate, and a β-lactone has been developed. This has been successfully applied to the enantio- and diastereoselective synthesis of the fully functionalized furopyran moiety of azadirachtins.