Descriptive epidemiology of Creutzfeldt-Jakob disease in Chile.
Descriptive epidemiology of Creutzfeldt-Jakob disease in Chile.
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智利克雅氏病的描述性流行病学。
DOI：
10.1001/archneur.1980.00500500041004
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发表时间：
1980
影响因子：
--
通讯作者：
C. Gajdusek
中科院分区：
文献类型：
--
作者：
S. Gálvez;C. Masters;C. Gajdusek
描述性流行病学资料来自1955年至1977年期间在智利发生的35例克雅氏病（CJD）的调查。将智利的平均死亡率（每百万人0.31例死亡）和圣地亚哥城市的平均死亡率（每百万人0.73例死亡）与其他国家报告的数据进行了比较。近年来发病率的上升可能与人们对这种疾病的认识提高有关。描述了来自5个受影响家庭的9例CJD患者的家族性发生，其分析表明遗传决定的易感性，潜伏期超过30年。该疾病的水平传播可能发生在一名患者中，该患者在与其他七名受影响成员结婚后13年发病。
Descriptive epidemiological data are presented from a survey of 35 cases of Creutzfeldt-Jakob disease (CJD) that occurred in Chile in the period 1955 to 1977. The average mortality in Chile (0.31 deaths per 1 million) and in urban Santiago (0.73 deaths per 1 million) is compared with data reported from other countries. An increasing incidence in recent years is probably related to a greater awareness of the disease. The familial occurrence of CJD in nine patients from five affected families is described, and its analysis suggests a genetically determined susceptibility with incubation periods of more than 30 years. Horizontal transmission of the disease may have occurred in one patient in whom the disease developed 13 years after the patient married into a family with seven other affected members.