IMMUNOHISTOCHEMICAL ANALYSIS OF ESTROGEN-RECEPTORS, PROGESTERONE RECEPTORS AND KI-67 IN LEIOMYOMA AND MYOMETRIUM DURING THE MENSTRUAL-CYCLE AND PREGNANCY
IMMUNOHISTOCHEMICAL ANALYSIS OF ESTROGEN-RECEPTORS, PROGESTERONE RECEPTORS AND KI-67 IN LEIOMYOMA AND MYOMETRIUM DURING THE MENSTRUAL-CYCLE AND PREGNANCY
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DOI：
10.1007/bf01606522
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发表时间：
1991-01-01
期刊：
影响因子：
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通讯作者：
MORI, T
中科院分区：
文献类型：
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作者：
KAWAGUCHI, K;FUJII, S;MORI, T
雌激素受体（ER），孕激素受体（PR）和细胞增殖相关抗原Ki-67的免疫组织化学分布在子宫肌瘤和子宫肌层在月经周期和妊娠进行了研究。在子宫肌层中，ER表达在增殖期观察到，但在分泌期和妊娠期间被抑制。在平滑肌瘤中，ER表达在整个月经周期中被观察到，但在妊娠期间被抑制。然而，PR在整个月经周期和怀孕期间在子宫肌层和平滑肌瘤中都有表达。在子宫肌层和平滑肌瘤，更多的Ki-67阳性细胞在怀孕期间观察到比在分泌期，Ki-67是阴性的绝经期。Ki-67阳性细胞计数在子宫肌瘤中显着高于肌层在整个月经周期和妊娠。因此，在高孕酮水平的激素环境下，子宫肌层和平滑肌瘤都具有高生长活性。在整个月经周期和妊娠期间，子宫平滑肌瘤的生长潜力明显高于子宫肌层。
Immunohistochemical distribution of oestrogen receptors (ER), progesterone receptors (PR), and the cell proliferation-associated antigen Ki-67 was investigated in leiomyomas and the myometrium during the menstrual cycle and pregnancy. In the myometrium, ER expression was observed in the proliferative phase, but was suppressed in the secretory phase and during pregnancy. In leiomyomas, ER expression was observed throughout the menstrual cycle, but was suppressed during pregnancy. However, PR was expressed both in the myometrium and leiomyomas throughout the menstrual cycle and pregnancy. In both the myometrium and leiomyomas, a higher number of Ki-67-positive cells was observed during pregnancy than in the secretory phase, and Ki-67 was negative during menopause. The Ki-67-positive cell count in leiomyomas was significantly higher than that in the myometrium throughout the menstrual cycle and pregnancy. Thus both myometrium and leiomyomas have high growth activity under the hormonal milieu of high progesterone levels. The growth potential of leiomyomas is apparently higher than that of myometrium throughout the menstrual cycle and during pregnancy.