Mitochondria in the human heart
Mitochondria in the human heart
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DOI：
10.1007/s10863-009-9211-0
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发表时间：
2009-04-01
影响因子：
3
通讯作者：
Hoppel, C. L.
中科院分区：
文献类型：
--
作者：
Lemieux, H.;Hoppel, C. L.
心脏主要依靠线粒体代谢来提供泵送血液给身体各器官充氧所需的能量。人类心脏线粒体功能的研究面临许多障碍，线粒体在心脏疾病中的作用的阐明主要依赖于动物模型的研究。心脏病是全世界死亡的主要原因。随着治疗和预防心脏病的新疗法的出现，一些旨在代谢调节，对人类心脏中线粒体功能的更好理解的需求变得明显。我们的综述旨在从以下方面对人类心脏进行具体评估：(1)了解线粒体功能的方法，特别强调综合功能；(2)线粒体功能障碍在心血管疾病中的作用的数据；(3)这些知识在心脏病患者治疗中的可能应用。
The heart relies mainly on mitochondrial metabolism to provide the energy needed for pumping blood to oxygenate the organs of the body. The study of mitochondrial function in the human heart faces many obstacles and elucidation of the role of mitochondria in cardiac diseases has relied mainly on studies with animal models. Cardiac diseases are the leading cause of mortality worldwide. With the emergence of new therapies to treat and prevent heart disease, some aiming at metabolic modulation, a need for acquiring a better understanding of mitochondrial function in the human heart becomes apparent. Our review is aimed at specific evaluation of the human heart in terms of (1) methods to understand mitochondrial function, with particular emphasis on integrated function, (2) data on the role of mitochondrial dysfunction in cardiovascular disease, and (3) possible applications of this knowledge in the treatment of patients with cardiac disease.