Bacterial vaginosis and anaerobic bacteria are associated with endometritis
Bacterial vaginosis and anaerobic bacteria are associated with endometritis
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DOI：
10.1086/423963
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发表时间：
2004-10-01
影响因子：
11.8
通讯作者：
Ness, RB
中科院分区：
文献类型：
--
作者：
Haggerty, CL;Hillier, SL;Ness, RB
背景资料。沙眼衣原体和/或淋病奈瑟菌约占盆腔炎病例的三分之一到一半。因此，高达70%的病例有未知的非淋球菌/非衣原体微生物病原学。我们调查了278名有完整子宫内膜组织学和培养的妇女中淋球菌、沙眼衣原体、细菌性阴道病、厌氧菌、兼性细菌和乳杆菌与子宫内膜炎的关系。患有急性子宫内膜炎的女性感染H-2O-2乳杆菌的可能性较小(优势比[OR]，0.1；95%可信区间[CI]，0.01-0.8)，更有可能感染沙眼衣原体(OR，16.2；95%CI，4.6-56.6)、淋球菌(OR，11.6；95%CI，4.5-29.9)、类白喉(OR，5.0；95%CI，2.1~12.2)，黑色革兰氏阴性杆菌(OR，3.1；95%CI，1.4~7.0)，厌氧革兰阳性球菌(OR，2.1；95%CI，1.0~4.3)，细菌性阴道病(OR 2.4；95%CI，1.3~4.3)。我们得出结论，细菌性阴道病相关微生物在患有盆腔炎的妇女中很常见。由于这些细菌与子宫内膜炎密切相关，我们建议所有患有盆腔炎的妇女都应该接受包括甲硝唑在内的治疗方案。
Background. Chlamydia trachomatis and/ or Neisseria gonorrhoeae account for approximately one- third to one- half of pelvic inflammatory disease ( PID) cases. Thus, up to 70% of cases have an unknown, nongonococcal/ nonchlamydial microbial etiology.Methods. We investigated the associations of N. gonorrhoeae, C. trachomatis, bacterial vaginosis, anaerobic bacteria, facultative bacteria, and lactobacilli with endometritis among 278 women with complete endometrial histology and culture from the PID Evaluation and Clinical Health Study.Results. Women with acute endometritis were less likely to have H-2 O-2- producing Lactobacillus species ( odds ratio [ OR], 0.1; 95% confidence interval [ CI], 0.01 - 0.8) and more likely to be infected with C. trachomatis ( OR, 16.2; 95% CI, 4.6 - 56.6), N. gonorrhoeae ( OR, 11.6; 95% CI, 4.5 - 29.9), diphtheroids ( OR, 5.0; 95% CI, 2.1 - 12.2), black- pigmented gram- negative rods ( OR, 3.1; 95% CI, 1.4 - 7.0), and anaerobic gram- positive cocci ( OR, 2.1; 95% CI, 1.0 - 4.3) and to have bacterial vaginosis ( OR, 2.4; 95% CI, 1.3 - 4.3).Conclusions. We conclude that bacterial vaginosis - associated organisms are frequent among women with PID. Because these organisms were strongly associated with endometritis, we recommend that all women with PID be treated with regimens that include metronidazole.