Abscisic Acid as Pathogen Effector and Immune Regulator.
Abscisic Acid as Pathogen Effector and Immune Regulator.
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DOI：
10.3389/fpls.2017.00587
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发表时间：
2017
影响因子：
5.6
通讯作者：
Staal J
中科院分区：
文献类型：
--
作者：
Lievens L;Pollier J;Goossens A;Beyaert R;Staal J
脱落酸（阿坝）是一种倍半萜信号分子，在所有生命王国中产生。迄今为止，阿坝最为人所知的功能是其作为一种主要的植物激素在植物非生物胁迫抗性中的作用。不同的生物体发展了不同的ABA生物合成和信号转导途径。尽管如此，也有有趣的共同主题，其中阿坝经常抑制宿主免疫反应，并被病原体用作效应分子。阿坝似乎也在相容的互利相互作用中发挥重要作用，如菌根和根际细菌与植物，也可能是动物肠道微生物组。阿坝在种间通讯中的频繁使用可能是阿坝作为信号分子在不同生物中广泛分布和重新发明的一个可能原因。在人类和动物模型中，已经表明阿坝治疗或营养来源的阿坝对炎症性疾病如结肠炎和2型糖尿病有益，这赋予阿坝作为一种有趣的营养药物或生药学药物的潜力。阿坝治疗在人类和动物模型中的抗炎活性、细胞代谢重编程和其他有益的生理和心理效应已经引发了对该分子及其信号传导途径作为新的药理学靶点的兴趣。然而，与植物相比，对其他生物中ABA的生物合成和信号传导知之甚少。来自植物科学和植物病原真菌研究的关于阿坝的基因、工具和知识可能有益于内源产生的阿坝在人类中的生理作用的生物医学研究。
Abscisic acid (ABA) is a sesquiterpene signaling molecule produced in all kingdoms of life. To date, the best known functions of ABA are derived from its role as a major phytohormone in plant abiotic stress resistance. Different organisms have developed different biosynthesis and signal transduction pathways related to ABA. Despite this, there are also intriguing common themes where ABA often suppresses host immune responses and is utilized by pathogens as an effector molecule. ABA also seems to play an important role in compatible mutualistic interactions such as mycorrhiza and rhizosphere bacteria with plants, and possibly also the animal gut microbiome. The frequent use of ABA in inter-species communication could be a possible reason for the wide distribution and re-invention of ABA as a signaling molecule in different organisms. In humans and animal models, it has been shown that ABA treatment or nutrient-derived ABA is beneficial in inflammatory diseases like colitis and type 2 diabetes, which confer potential to ABA as an interesting nutraceutical or pharmacognostic drug. The anti-inflammatory activity, cellular metabolic reprogramming, and other beneficial physiological and psychological effects of ABA treatment in humans and animal models has sparked an interest in this molecule and its signaling pathway as a novel pharmacological target. In contrast to plants, however, very little is known about the ABA biosynthesis and signaling in other organisms. Genes, tools and knowledge about ABA from plant sciences and studies of phytopathogenic fungi might benefit biomedical studies on the physiological role of endogenously generated ABA in humans.