Asymmetric synthesis of a cytotoxic amide of Telesto riisei
Asymmetric synthesis of a cytotoxic amide of Telesto riisei
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DOI：
10.1016/s0957-4166(98)00091-3
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发表时间：
1998-04-24
影响因子：
--
通讯作者：
Chattopadhyay, S
中科院分区：
文献类型：
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作者：
Sankaranarayanan, S;Chattopadhyay, S
以环己叉基甘油醛1为手性模板，利用Telesto riisei的细胞毒性原理，有效地合成了N-（2-苯乙基）-8-羟基十五酰胺的两种对映体。与醛1的非立体选择性格氏加成得到所需手性3-烷基甘油的C-3差向异构体，其通过标准反应顺序转化为标题化合物。(C)1998由Elsevier Science Ltd.出版。保留所有权利。
An efficient synthesis of both the enantiomers of N-(2-phenylethyl)-8-hydroxypentadecacarboxamide using the cytotoxic principles of Telesto riisei has been formulated using cyclohexylideneglyceraldehyde 1 as the chiral template. A non-stereoselective Grignard addition to the aldehyde 1 gave the C-3 epimers of the required chiron, 3-alkylglycerol which were converted to the title compound via a standard sequence of reactions. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.