Mould and dampness in dwelling places, and onset of asthma: the population-based cohort ECRHS
Mould and dampness in dwelling places, and onset of asthma: the population-based cohort ECRHS
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DOI：
10.1136/oemed-2012-100963
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发表时间：
2013-05-01
影响因子：
4.9
通讯作者：
Jarvis, Deborah
中科院分区：
文献类型：
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作者：
Norback, Dan;Zock, Jan-Paul;Jarvis, Deborah
目的研究成人新发哮喘与居所潮湿和霉菌的关系。方法前瞻性跟踪调查来自13个国家的7104名未报告呼吸道症状或哮喘的青年，这些青年来自13个国家。通过哮喘症状问卷调查数据和元胆碱激发试验阳性在随访时评估哮喘。在跟踪期开始和结束时，通过面试者主导的问卷和检查，收集了关于当前住所的数据。根据年龄、性别、吸烟和研究中心调整后的对数二项模型计算新发哮喘的相对危险度(RR)。结果在基线时，有水损害(RR 1.46；95%CI 1.09~1.94)和室内霉菌(RR=1.30；95%CI 1.00~1.68)的受试者新发哮喘的风险过高。观察到了剂量-反应效应。这种影响在那些具有多重敏感性的人和那些对霉菌敏感的人中更强。观察到的湿点与新发哮喘有关(RR=1.49；95%CI为1.00~2.22)。报告的人群归因危险度为3-10%，观察到的潮湿/霉菌的人群归因危险度为3-14%。结论潮湿和霉菌在住宅中普遍存在，并与成人哮喘的发病有关。
Objectives To study new onset of adult asthma in relation to dampness and moulds in dwelling places.Methods Totally, 7104 young adults from 13 countries who participated in the European Community Respiratory Health Survey (ECRHS I and II) who did not report respiratory symptoms or asthma at baseline were followed prospectively for 9 years. Asthma was assessed by questionnaire data on asthmatic symptoms and a positive metacholine challenge test at follow-up. Data on the current dwelling was collected at the beginning and at the end of the follow-up period by means of an interviewer-led questionnaire, and by inspection. Relative risks (RR) for new onset asthma were calculated with log-binomial models adjusted for age, sex, smoking and study centre.Results There was an excess of new asthma in subjects in homes with reports on water damage (RR 1.46; 95% CI 1.09 to 1.94) and indoor moulds (RR=1.30; 95% CI 1.00 to 1.68) at baseline. A dose-response effect was observed. The effect was stronger in those with multisensitisation and in those sensitised to moulds. Observed damp spots were related to new asthma (RR=1.49; 95% CI 1.00 to 2.22). The population-attributable risk was 3-10% for reported, and 3-14% for observed dampness/moulds.Conclusions Dampness and mould are common in dwellings, and contribute to asthma incidence in adults.