Universal standardization of bone density measurements: A method with optimal properties for calibration among several instruments
Universal standardization of bone density measurements: A method with optimal properties for calibration among several instruments
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DOI：
10.1359/jbmr.1997.12.9.1463
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发表时间：
1997-09-01
影响因子：
6.2
通讯作者：
Genant, H
中科院分区：
文献类型：
--
作者：
Hui, SL;Gao, SJ;Genant, H
国际双光子X射线吸收测量（DXA）标准化委员会（IDSC）对来自三个不同制造商的三种型号的DXA机器进行了交叉校准研究。在这项研究中，100名受试者在所有三台机器上进行了扫描。推导出一组方程，将每台机器上的骨矿物质密度（BMD）转换为“标准化BMD”（sBMD），使得来自不同机器的同一受试者的sBMD大致相同。在交叉校准数据的重新分析中，我们发现IDSC研究中使用的转换方法在这种转换中没有实现几个理想的最佳特性。我们推导出新的转换方程sBMD的基础上，最大限度地减少sBMD之间的差异，从三台机器。更重要的是，新的转换没有残留的偏见，目前在IDSC转换。在交叉校准数据和外部数据集上比较了方法的性能。我们的结论是，IDSC转换是足够的临床使用在世界各地的其他机器上，但研究人员应该标准化自己的机器在实验室中使用的新方法。
The International Dual-Photon X-Ray Absorptiometry (DXA) Standardization Committee (IDSC) conducted a cross-calibration study among three models of DXA machines from three different manufacturers. In that study, 100 subjects were scanned on all three machines. A set of equations were derived to convert bone mineral density (BMD) on each machine to a ''standardized BMD'' (sBMD) such that sBMD from the same subject derived from different machines would be approximately the same. In a reanalysis of the cross-calibration data, we showed that the conversion method used in the IDSC study did not achieve several optimal properties desirable in such conversions. We derived new conversion equations to sBMD based on minimizing differences among sBMD from the three machines. More important is that the new conversions have no residual bias that was present in the IDSC conversions. The performance of the methods were compared on the cross-calibration data as well as an external data set. We conclude that the IDSC conversions are adequate for clinical use on other machines worldwide, but that researchers should standardize their own machines in a laboratory using the new method.