Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study
Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study
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DOI：
10.1093/eurheartj/ehq465
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发表时间：
2011-05-01
影响因子：
39.3
通讯作者：
Riboli, Elio
中科院分区：
文献类型：
--
作者：
Crowe, Francesca L.;Roddam, Andrew W.;Riboli, Elio
目的水果和蔬菜的摄入量越多，患缺血性心脏病(IHD)的风险越低，但对这种联系的解释还存在一些不确定性。在欧洲癌症和营养前瞻性调查(EPIC)-心脏研究中，目的是评估水果和蔬菜的摄入与IHD死亡风险的关系。方法与结果：经过平均8.4年的随访，来自8个欧洲国家的313 074名没有心肌梗死或中风病史的男性和女性中，有1636人死于IHD。每天摄入至少8份水果和蔬菜(每人80克)的参与者与每天摄入少于3份水果和蔬菜的参与者相比，患致命IHD的风险低22%[相对风险(RR)=0.78，95%可信区间(CI)：0.65-0.95]。在校正了水果和蔬菜的摄入量以考虑参与中心之间的饮食评估差异后，水果和蔬菜摄入量增加一个部分(80g)与致命的IHD的风险降低4%相关(RR=0.9695%CI：0.921.00，P for Trend=0.033)。结论这项大型观察性研究的结果表明，较高的水果和蔬菜摄入量与IHD死亡率的降低相关。这种关联是否是因果关系，如果是，水果和蔬菜降低IHD风险的生物学机制(S)尚不清楚。
Aims A higher intake of fruits and vegetables has been associated with a lower risk of ischaemic heart disease (IHD), but there is some uncertainty about the interpretation of this association. The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study.Methods and results After an average of 8.4 years of follow-up, there were 1636 deaths from IHD among 313 074 men and women without previous myocardial infarction or stroke from eight European countries. Participants consuming at least eight portions (80 g each) of fruits and vegetables a day had a 22% lower risk of fatal IHD [relative risk (RR) = 0.78, 95% confidence interval (CI): 0.65-0.95] compared with those consuming fewer than three portions a day. After calibration of fruit and vegetable intake to account for differences in dietary assessment between the participating centres, a one portion (80 g) increment in fruit and vegetable intake was associated with a 4% lower risk of fatal IHD (RR = 0.96, 95% CI: 0.92-1.00, P for trend = 0.033).Conclusion Results from this large observational study suggest that a higher intake of fruits and vegetables is associated with a reduced risk of IHD mortality. Whether this association is causal and, if so, the biological mechanism(s) by which fruits and vegetables operate to lower IHD risks remains unclear.