Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence
Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence
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DOI：
10.1016/j.neuroimage.2010.06.024
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发表时间：
2010-11-01
期刊：
影响因子：
5.7
通讯作者：
Chetelat, Gael
中科院分区：
文献类型：
--
作者：
La Joie, Renaud;Fouquet, Marine;Chetelat, Gael
神经影像学的最新进展突出了对认知神经科学区分海马亚区的兴趣，更值得注意的是在评估正常和病理老化的影响方面。本研究的主要目标是研究正常老化对不同海马亚区体积的影响。我们开发了一种新的磁共振序列以及可靠的跟踪指南，以使用3特斯拉扫描仪评估海马体不同子区域的体积，并基于广泛使用的自动基于体素的形态测定（VBM）技术来估计更简单和更少耗时的方法的有效性。在50名18至68岁之间的健康受试者的右和左海马上描绘了三个感兴趣的海马区，海马下托及其它亚区（包括CA 2 -3-4和齿状回）的体积随年龄的增长，只有海马下托的体积随年龄的增长而减小，与整体灰质体积的减小相平行，而CA 1及其它亚区的体积则相对较小。虽然不如ROI跟踪技术精确，但基于VBM的方法似乎是一种可靠的替代方法，特别是在区分CA 1和下托亚区方面。我们的研究结果表明，年龄对下托的特定影响与发育假说一致。（“后进先出”理论）这与先前几项研究中报道的CA 1亚区对阿尔茨海默病的主要脆弱性形成对比，提示海马子区域的评估可能改善正常和病理性衰老之间的区分（C）2010 Elsevier Inc保留所有权利
Recent advances in neuroimaging have highlighted the interest to differentiate hippocampal subfields for cognitive neurosciences and more notably in assessing the effects of normal and pathological aging The main goal of the present study is to investigate the effects of normal aging onto the volume of the different hippocampal subfields For this purpose, we developed a new magnetic resonance sequence together with reliable tracing guidelines to assess the volume of different subfields of the hippocampus using a 3 Tesla scanner, and estimated the validity of a simpler and less time-consuming method based on the widely-used automatic Voxel-Based Morphometry (VBM) technique Three hippocampal regions of Interest were delineated on the right and left hippocampi of 50 healthy subjects between 18 and 68 years old corresponding to the CA1, subiculum and other (Including CA2-3-4 and Dentate Gyrus) subfields A strong effect of age was found on the volume of the subiculum only, with a decrease paralleling that of the global gray matter volume, while CA1 and other subfields seemed relatively spared. Although less precise than the ROI-tracing technique, the VBM-based method appeared as a reliable alternative especially to distinguish CA1 and subiculum subfields Our findings of a specific effect of age on the subiculum are consistent with the developmental hypothesis ("last-in first-out" theory) This contrasts with the predominant vulnerability of the CA1 subfield to Alzheimer's disease reported in several previous studies, suggesting that the assessment of hippocampal subfields may Improve the discrimination between normal and pathological aging (C) 2010 Elsevier Inc All rights reserved