Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases.
Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases.
复制标题
DOI：
10.3390/nu15010047
复制
发表时间：
2022-12-22
期刊：
影响因子：
5.9
通讯作者：
Varga JT
中科院分区：
文献类型：
--
作者：
Fekete M;Szarvas Z;Fazekas-Pongor V;Feher A;Csipo T;Forrai J;Dosa N;Peterfi A;Lehoczki A;Tarantini S;Varga JT
背景资料：越来越多的研究表明，饮食在调节衰老过程中起着重要作用，并调节最重要的年龄相关疾病的发展。目的：本综述的目的是提供一个概述的营养和严重的年龄相关疾病之间的关系。研究方法：本文综述了近年来有关营养因子在调节衰老的基本细胞和分子机制中的作用及其在预防衰老疾病发生中的作用的临床前和临床研究结果。结果如下：研究表明，某些具有抗衰老作用的饮食可以减缓或预防心脑血管疾病、神经退行性疾病、认知障碍和痴呆症的发展。饮食的保护作用，至少部分地，可以通过其有益的宏量（蛋白质，脂肪，碳水化合物）和微量营养素（维生素，矿物质）组成来介导。结论：某些饮食，例如地中海饮食，可能通过预防某些疾病的发生和改善衰老过程本身，在健康衰老中发挥重要作用。后者可以通过将禁食元素纳入饮食来加强。由于饮食建议随着年龄的变化而变化，因此在制定适合老年人需求的饮食时也应该考虑到这一点。未来和正在进行的关于复杂的抗衰老饮食干预的临床研究转化了临床前研究的结果，预计将在不久的将来为老年人提供新的营养指南。
Background: An increasing number of studies suggest that diet plays an important role in regulating aging processes and modulates the development of the most important age-related diseases. Objective: The aim of this review is to provide an overview of the relationship between nutrition and critical age-associated diseases. Methods: A literature review was conducted to survey recent pre-clinical and clinical findings related to the role of nutritional factors in modulation of fundamental cellular and molecular mechanisms of aging and their role in prevention of the genesis of the diseases of aging. Results: Studies show that the development of cardiovascular and cerebrovascular diseases, neurodegenerative diseases, cognitive impairment and dementia can be slowed down or prevented by certain diets with anti-aging action. The protective effects of diets, at least in part, may be mediated by their beneficial macro- (protein, fat, carbohydrate) and micronutrient (vitamins, minerals) composition. Conclusions: Certain diets, such as the Mediterranean diet, may play a significant role in healthy aging by preventing the onset of certain diseases and by improving the aging process itself. This latter can be strengthened by incorporating fasting elements into the diet. As dietary recommendations change with age, this should be taken into consideration as well, when developing a diet tailored to the needs of elderly individuals. Future and ongoing clinical studies on complex anti-aging dietary interventions translating the results of preclinical investigations are expected to lead to novel nutritional guidelines for older adults in the near future.
影响因子：
7.8
作者：
通讯作者：
--
影响因子：
4.3
作者：
Sinha A;Metzner C;Davey N;Adams R;Schmuker M;Steuber V
通讯作者：
Steuber V
影响因子：
7.4
作者：
Ladurner, Angela;Schmitt, Christoph A.;Schachner, Daniel;Atanasov, Atanas G.;Werner, Ernst R.;Dirsch, Verena M.;Heiss, Elke H.
通讯作者：
Heiss, Elke H.