Developmental Refining of Neuroglial Signaling?
Developmental Refining of Neuroglial Signaling?
复制标题
神经胶质信号的发育细化？
DOI：
10.1126/science.1233208
复制
发表时间：
2013
期刊：
影响因子：
56.9
通讯作者：
Reichenbach A
中科院分区：
文献类型：
--
作者：
Grosche A;Reichenbach A
当德国病理学家鲁道夫·魏尔啸（Rudolf Virchow）在1856年提出神经胶质（neuroglia）一词时，它就像一个耻辱，分散了任何著名神经科学家对这些细胞进行研究的注意力。世纪后，对神经胶质细胞进行了深入的研究，并最终提出了三重突触的概念，根据这一概念，星形胶质细胞（一种主要类型的神经胶质细胞）通过增加其内部钙（Ca 2+）浓度来响应神经元活动，这触发了神经胶质细胞自身释放化学递质，进而导致神经元活动和突触强度的反馈调节。虽然这一概念在神经科学家中被广泛接受，但现在它受到了挑战。在这期杂志的第197页，Sunet等人发现，成年人大脑中的神经轴突信号可能以一种与发育过程中完全不同的方式发生。
When the term neuroglia (“nerve-putty”) was introduced by the German pathologist Rudolf Virchow in 1856 , it was like a stigma, distracting any reputable neuroscientist from doing research on these cells. More than a century later, intense research on glial cells was performed and culminated in the concept of the tripartite synapse, according to which astrocytes (a main type of glia) respond to neuronal activity by increasing their internal calcium (Ca2÷) concentration, which triggers the release of chemical transmitters from glia themselves and, in turn, causes feedback regulation of neuronal activity and synaptic strength . Although this concept became widely accepted among neuroscientists, it has now been challenged. On page 197 in this issue, Sunet al.find that neuronglia signaling in the adult brain may occur in a manner fundamentally distinct from that exhibited during development.