Resting State Cortical Oscillations of Patients With Parkinson Disease and With and Without Subthalamic Deep Brain Stimulation: A Magnetoencephalography Study
Resting State Cortical Oscillations of Patients With Parkinson Disease and With and Without Subthalamic Deep Brain Stimulation: A Magnetoencephalography Study
复制标题
帕金森病患者在有或没有丘脑深部刺激的情况下的静息态皮质振荡：脑磁图研究
DOI：
10.1097/wnp.0000000000000137
复制
发表时间：
2015-04-01
影响因子：
2.4
通讯作者：
Sun, Bomin
中科院分区：
文献类型：
--
作者：
Cao, Chunyan;Li, Dianyou;Sun, Bomin
目的：探讨丘脑深部电刺激(STN-DBS)对帕金森病(PD)患者皮层震荡的调节作用。方法：用脑磁图记录帕金森病患者在丘脑底核深部刺激状态下的自发性皮层振荡。在频域中提取了感兴趣区域的平均频率、平均功率和相对子带功率等特征，并将这些特征与统一帕金森病评定量表III进行了相关评估。同样的特征也被研究在未做手术的帕金森病患者和健康对照组。结果：未经手术的帕金森病患者与健康对照组相比，在1~48赫兹范围内，帕金森病患者的平均频率显著降低，平均功率显著增加。帕金森病患者的额叶相对功率较高，颞叶和枕叶的β和伽马同时降低。帕金森病统一评定量表III的僵硬评分与额区的平均频率以及β和伽马的相对功率相关。丘脑底核深部刺激时，刺激开启时的平均频率较关闭时显著增加。此外，三角洲的相对功率下降，而整个大脑皮层的β功率上升。在刺激过程中，统一帕金森病评定量表III的僵硬程度和震颤评分与阿尔法对左顶叶的相对功率相关。结论：丘脑底核深部电刺激通过抑制躯体运动区α节律的同步性改善帕金森病的症状。
Purpose: In this study, we investigate the modification to cortical oscillations of patients with Parkinson disease (PD) by subthalamic deep brain stimulation (STN-DBS). Methods: Spontaneous cortical oscillations of patients with PD were recorded with magnetoencephalography during on and off subthalamic nucleus deep brain stimulation states. Several features such as average frequency, average power, and relative subband power in regions of interest were extracted in the frequency domain, and these features were correlated with Unified Parkinson Disease Rating Scale III evaluation. The same features were also investigated in patients with PD without surgery and healthy controls. Results: Patients with Parkinson disease without surgery compared with healthy controls had a significantly lower average frequency and an increased average power in 1 to 48 Hz range in whole cortex. Higher relative power in theta and simultaneous decrease in beta and gamma over temporal and occipital were also observed in patients with PD. The Unified Parkinson Disease Rating Scale III rigidity score correlated with the average frequency and with the relative power of beta and gamma in frontal areas. During subthalamic nucleus deep brain stimulation, the average frequency increased significantly when stimulation was on compared with off state. In addition, the relative power dropped in delta, whereas it rose in beta over the whole cortex. Through the course of stimulation, the Unified Parkinson Disease Rating Scale III rigidity and tremor scores correlated with the relative power of alpha over left parietal. Conclusions: Subthalamic nucleus deep brain stimulation improves the symptoms of PD by suppressing the synchronization of alpha rhythm in somatomotor region.