Bacterial flagellar axial structure and its construction.
Bacterial flagellar axial structure and its construction.
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DOI：
10.1007/s12551-017-0378-z
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发表时间：
2018-04-01
影响因子：
--
通讯作者：
Imada, Katsumi
中科院分区：
文献类型：
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作者：
Imada, Katsumi
细菌鞭毛是由数千个蛋白质亚基组成的活动细胞器。从细胞膜延伸出来的丝状部分称为轴向结构，由丝、钩和杆三个主要部分和其他次要部分组成。三个主要部件中的每一个都具有相似的自组装机制和共同的亚单元排列的基本结构，同时表现出截然不同的机械性能来实现其特定的功能。通过x射线晶体学和低温电子显微镜的互补使用，揭示了产生这些轴向结构（如丝、钩和棒）的各种机械性能的结构和分子机制。此外，基于分子结构的轴向结构的生长机理也开始被揭示。
The bacterial flagellum is a motile organelle composed of thousands of protein subunits. The filamentous part that extends from the cell membrane is called the axial structure and consists of three major parts, the filament, hook, and rod, and other minor components. Each of the three main parts shares a similar self-assembly mechanism and a common basic architecture of subunit arrangement while showing quite distinct mechanical properties to achieve its specific function. Structural and molecular mechanisms to produce these various mechanical properties of the axial structure, such as the filament, the hook, and the rod, have been revealed by the complementary use of X-ray crystallography and cryo-electron microscopy. In addition, the mechanism of growth of the axial structure is beginning to be revealed based on the molecular structure.