More than markers: biological significance of cancer stem cell-defining molecules.
More than markers: biological significance of cancer stem cell-defining molecules.
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DOI：
10.1158/1535-7163.mct-10-0530
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发表时间：
2010-09
影响因子：
5.7
通讯作者：
Jimeno A
中科院分区：
文献类型：
--
作者：
Keysar SB;Jimeno A
在越来越多的实体肿瘤中，标记的肿瘤干细胞(CSC)或肿瘤起始细胞(TIC)具有在体内分化、自我更新和复制原始肿瘤的能力。到目前为止，这些细胞通过细胞表面蛋白(如CD24、CD44、CD133)的表达模式和细胞活动(如Hoechst染料的外流或ALDH活性)与实体瘤群体区分开来。最近的数据表明，这些标记物可以被抗癌药物诱导，这既突出了CSC隔室的潜在流动性，也强调了这些标记物的功能。CD44在侵袭、黏附和转移中的作用，或CD24在调节src、FAK和GLI1中的作用都是这些相关作用的例子。我们希望阐明这些标记物和活性在肿瘤进展、转移和可能的治疗靶点中所起的生物学意义，而不是仅仅关注这些人群中的标记物的表达。
Small populations within an increasing array of solid tumors, labeled cancer stem cells (CSC) or tumor initiating cells (TIC), have the ability to differentiate, self-renew and replicate the original tumor in vivo. To date these cells have been distinguished from the bulk tumor population by the expression pattern of cell surface proteins (e.g. CD24, CD44, CD133) and cellular activities such as the efflux of Hoechst dye or ALDH activity. Recent data has shown that these markers are inducible by exposure to anticancer agents, which highlights both the potential fluidity of the CSC compartment, but also the functionality of these markers. The involvement of CD44 in invasion, adhesion, and metastasis, or the role of CD24 in modulation src, FAK, and GLI1 are examples of these relevant roles. Instead of looking solely at the marker expression in these populations we hope to clarify the biologically significant roles these markers and activities play in tumor progression, metastases, and as possible targets for therapy.