MR perfusion-weighted imaging and quantitative analysis of cerebral hemodynamics with symptom provocation in unmedicated patients with obsessive-compulsive disorder
MR perfusion-weighted imaging and quantitative analysis of cerebral hemodynamics with symptom provocation in unmedicated patients with obsessive-compulsive disorder
复制标题
DOI：
10.1016/j.neulet.2004.08.019
复制
发表时间：
2004-11-11
影响因子：
2.5
通讯作者：
Zhang, BQ
中科院分区：
文献类型：
--
作者：
Chen, XL;Xie, JX;Zhang, BQ
我们评估了动态增强灌注加权成像(PWI)在确定脑结构血流动力学激活方面的潜在有效性，这可能涉及强迫症(OCD)患者的症状，表现为对洗涤强迫的污染痴迷。对10例未服药的女性强迫症患者进行PWI检查，比较症状激发前后各感兴趣区的相对脑血流量(RCBF)和强迫症症状自评。我们发现焦虑类比量表(AAS)和强迫症类比量表(OCDAS)分数的增加都与挑衅显著相关。在控制和激发条件下，OCDAS和AAS得分之间的相关性在统计学上也是显著的。与对照组相比，症状期大鼠右侧尾状核头部、丘脑和双侧眶前叶皮质rCBF显著增加。双侧扣带回前皮质(ACC)的rCBF无统计学变化。这些发现表明，强迫症的症状伴随着焦虑，异常特征在眼眶额叶-皮质下环路中尤为明显。(C)2004爱思唯尔爱尔兰有限公司。保留所有权利。
We evaluated the potential effectiveness of dynamic contrast-enhanced perfusion-weighted images (PWI) in determining hemodynamic activation in brain structures that may be involved in mediating the symptomatology of patients with obsessive-compulsive disorder (OCD), as manifested by contamination obsessions with washing compulsions. Ten unmedicated female patients with OCD were subjected to PWI, and relative cerebral blood flow (rCBF) in each region of interest (ROI) and self-ratings of OCD symptoms were compared before and after symptom provocation. We found that increases in the Anxiety Analogue Scale (AAS) and OCD Analogue Scale (OCDAS) scores were each significantly associated with provocation. The correlations between OCDAS and AAS scores were also statistically significant during both the control and provoked conditions. Compared with the control state, there was a significant increase in rCBF during the symptomatic state in the right head of caudate nucleus, thalamus, and bilateral orbitofrontal cortices (OFC). No statistical changes in rCBF were found in the bilateral anterior cingulate cortices (ACC). These findings demonstrate that OCD symptomatology is accompanied by anxiety, and that abnormal features are particularly apparent in the orbitofrontal-subcortical circuits. (C) 2004 Elsevier Ireland Ltd. All rights reserved.