An algorithm for the operational assessment of adverse drug reactions. I. Background, description, and instructions for use.
An algorithm for the operational assessment of adverse drug reactions. I. Background, description, and instructions for use.
复制标题
药物不良反应操作评估的算法。
DOI：
10.1001/jama.1979.03300070019017
复制
发表时间：
1979
期刊：
影响因子：
--
通讯作者：
A. Feinstein
中科院分区：
文献类型：
--
作者：
M. Kramer;J. Leventhal;T. Hutchinson;A. Feinstein
Despite widespread clinical and epidemiologic attention to adverse drug reactions (ADRs), their clinical identification has been a nonreproducible act of unspecified subjective judgment; adequate operational criteria have not been available for diagnostic decisions about the cause of an observed untoward clinical manifestation. To improve scientific precision in the diagnosis of ADRs, we have developed an algorithm that provides detailed operational criteria for ranking the probability of causation when ADR is suspected between a drug and a clinical manifestation. The algorithm provides a scoring system for six axes of decision strategy: previous general experience with the drug, alternative etiologic candidates, timing of events, drug levels and evidence of overdose, dechallenge, and rechallenge. The sum of the scores is ordinally partitioned to rate the candidate ADR as definite, probable, possible, or unlikely.
